Abstract：
BACKGROUND: Carbohydrate deficient transferrin (CDT) is a biomarker for excessive alcohol consumption utilized in clinical and forensic medicine and workplace testing. Previously, many different analytical methods for CDT were used and the measurand varied considerably, making direct comparison of test results difficult. To end this confusion, the IFCC established a working group on CDT standardisation (WG-CDT) which completed its tasks in 2017.
METHODS: This IFCC position paper by the WG-CDT summarizes state of the art information about the measurand and the analytical methods and gives concise recommendations for its utilization.
RESULTS: The results achieved by the CDT standardisation process led to accuracy improvements in national external quality assessment schemes over the years. A brief review of ROC based comparison studies with the traditional biomarkers (GGT, MCV, ALT and AST) discusses the bias resulting from inadequate study populations. In large groups of the general population the superior diagnostic performance of CDT is confirmed.
CONCLUSIONS: The relationship between alcohol intake versus resulting CDT is discussed as well as the cutoff and measurement uncertainty. Concerning the application in practice, potential pitfalls are considered and recommendations handling both analytical and preanalytical caveats are given. Finally, some examples of serious misunderstandings in publications about CDT are addressed.
METHODS: This IFCC position paper by the WG-CDT summarizes state of the art information about the measurand and the analytical methods and gives concise recommendations for its utilization.
RESULTS: The results achieved by the CDT standardisation process led to accuracy improvements in national external quality assessment schemes over the years. A brief review of ROC based comparison studies with the traditional biomarkers (GGT, MCV, ALT and AST) discusses the bias resulting from inadequate study populations. In large groups of the general population the superior diagnostic performance of CDT is confirmed.
CONCLUSIONS: The relationship between alcohol intake versus resulting CDT is discussed as well as the cutoff and measurement uncertainty. Concerning the application in practice, potential pitfalls are considered and recommendations handling both analytical and preanalytical caveats are given. Finally, some examples of serious misunderstandings in publications about CDT are addressed.
摘要：
背景：碳水化合物缺乏转铁蛋白（CDT）是临床和法医学以及工作场所测试中过度饮酒的生物标志物。以前,使用了许多不同的CDT分析方法，测量范围差异很大，使直接比较测试结果变得困难。为了结束这种混乱,IFCC成立了CDT标准化工作组（WG-CDT），该工作组于2017年完成了任务。
方法：WG-CDT撰写的这份IFCC立场文件总结了有关被测量和分析方法的最新信息，并为其使用提供了简明建议。
结果：CDT标准化过程所取得的结果导致了多年来国家外部质量评估计划的准确性提高。简要回顾了基于ROC的与传统生物标志物(GGT，MCV,ALT和AST)讨论了研究人群不足导致的偏差。在一般人群的大群体中，CDT的优异诊断性能得到证实。
结论：讨论了酒精摄入量与所产生的CDT之间的关系以及截止和测量不确定度。关于在实践中的应用，考虑了潜在的陷阱，并给出了处理分析和分析前警告的建议。最后,解决了出版物中有关CDT的严重误解的一些例子。
方法：WG-CDT撰写的这份IFCC立场文件总结了有关被测量和分析方法的最新信息，并为其使用提供了简明建议。
结果：CDT标准化过程所取得的结果导致了多年来国家外部质量评估计划的准确性提高。简要回顾了基于ROC的与传统生物标志物(GGT，MCV,ALT和AST)讨论了研究人群不足导致的偏差。在一般人群的大群体中，CDT的优异诊断性能得到证实。
结论：讨论了酒精摄入量与所产生的CDT之间的关系以及截止和测量不确定度。关于在实践中的应用，考虑了潜在的陷阱，并给出了处理分析和分析前警告的建议。最后,解决了出版物中有关CDT的严重误解的一些例子。
