Abstract：
BACKGROUND: Coffee is a complex brew that contains several bioactive compounds and some of them can influence blood pressure (BP) and endothelial function (EF), such as caffeine and chlorogenic acids (CGAs).
OBJECTIVE: This study aimed to evaluate the acute effects of coffee on BP and EF in individuals with hypertension on drug treatment who were habitual coffee consumers.
METHODS: This randomized crossover trial assigned 16 adults with hypertension to receive three test beverages one week apart: caffeinated coffee (CC; 135 mg caffeine, 61 mg CGAs), decaffeinated coffee (DC; 5 mg caffeine, 68 mg CGAs), and water. BP was continuously evaluated from 15 min before to 90 min after test beverages by digital photoplethysmography. Reactive hyperemia index (RHI) assessed by peripheral arterial tonometry evaluated EF before and at 90 min after test beverages. At the same time points, microvascular reactivity was assessed by laser speckle contrast imaging. Repeated-measures-ANOVA evaluated the effect of time, the effect of beverage, and the interaction between time and beverage (treatment effect).
RESULTS: Although the intake of CC produced a significant increase in BP and a significant decrease in RHI, these changes were also observed after the intake of DC and were not significantly different from the modifications observed after the consumption of DC and water. Microvascular reactivity did not present significant changes after the 3 beverages.
CONCLUSIONS: CC in comparison with DC and water neither promoted an acute increase in BP nor produced an improvement or deleterious effect on EF in individuals with hypertension on drug treatment who were coffee consumers.
OBJECTIVE: This study aimed to evaluate the acute effects of coffee on BP and EF in individuals with hypertension on drug treatment who were habitual coffee consumers.
METHODS: This randomized crossover trial assigned 16 adults with hypertension to receive three test beverages one week apart: caffeinated coffee (CC; 135 mg caffeine, 61 mg CGAs), decaffeinated coffee (DC; 5 mg caffeine, 68 mg CGAs), and water. BP was continuously evaluated from 15 min before to 90 min after test beverages by digital photoplethysmography. Reactive hyperemia index (RHI) assessed by peripheral arterial tonometry evaluated EF before and at 90 min after test beverages. At the same time points, microvascular reactivity was assessed by laser speckle contrast imaging. Repeated-measures-ANOVA evaluated the effect of time, the effect of beverage, and the interaction between time and beverage (treatment effect).
RESULTS: Although the intake of CC produced a significant increase in BP and a significant decrease in RHI, these changes were also observed after the intake of DC and were not significantly different from the modifications observed after the consumption of DC and water. Microvascular reactivity did not present significant changes after the 3 beverages.
CONCLUSIONS: CC in comparison with DC and water neither promoted an acute increase in BP nor produced an improvement or deleterious effect on EF in individuals with hypertension on drug treatment who were coffee consumers.
摘要：
背景：咖啡是一种复杂的冲泡，含有几种生物活性化合物，其中一些可以影响血压（BP）和内皮功能（EF），如咖啡因和绿原酸（CGAs）。
目的：本研究旨在评估习惯性咖啡消费者在药物治疗中咖啡对高血压患者BP和EF的急性影响。
方法：这项随机交叉试验分配了16名患有高血压的成年人，每隔一周接受三种测试饮料：含咖啡因的咖啡（CC；135毫克咖啡因，61毫克CGAs)，脱咖啡因咖啡（DC；5毫克咖啡因，68毫克CGAs)，和水。通过数字光电容积描记术从测试饮料前15分钟到测试饮料后90分钟连续评估BP。通过外周动脉张力测量法评估的反应性充血指数（RHI）在测试饮料之前和之后90分钟评估了EF。在同一时间点,通过激光散斑对比成像评估微血管反应性。重复测量方差分析评估了时间的影响，饮料的效果，以及时间和饮料之间的相互作用（治疗效果）。
结果：尽管CC的摄入使BP显着增加，RHI显着降低，这些变化在摄入DC后也观察到,与摄入DC和水之后观察到的变化没有显著差异.3种饮料后，微血管反应性没有显着变化。
结论：与DC和水相比，CC既不促进血压的急性增加，也不产生对EF的改善或有害作用。
目的：本研究旨在评估习惯性咖啡消费者在药物治疗中咖啡对高血压患者BP和EF的急性影响。
方法：这项随机交叉试验分配了16名患有高血压的成年人，每隔一周接受三种测试饮料：含咖啡因的咖啡（CC；135毫克咖啡因，61毫克CGAs)，脱咖啡因咖啡（DC；5毫克咖啡因，68毫克CGAs)，和水。通过数字光电容积描记术从测试饮料前15分钟到测试饮料后90分钟连续评估BP。通过外周动脉张力测量法评估的反应性充血指数（RHI）在测试饮料之前和之后90分钟评估了EF。在同一时间点,通过激光散斑对比成像评估微血管反应性。重复测量方差分析评估了时间的影响，饮料的效果，以及时间和饮料之间的相互作用（治疗效果）。
结果：尽管CC的摄入使BP显着增加，RHI显着降低，这些变化在摄入DC后也观察到,与摄入DC和水之后观察到的变化没有显著差异.3种饮料后，微血管反应性没有显着变化。
结论：与DC和水相比，CC既不促进血压的急性增加，也不产生对EF的改善或有害作用。
