Abstract：
Radiofrequency ablation is a nominally invasive technique to eradicate cancerous or non-cancerous cells by heating. However, it is still hampered to acquire a successful cell destruction process due to inappropriate RF intensities that will not entirely obliterate tumorous tissues, causing in treatment failure. In this study, we are acquainted with a nanoassisted RF ablation procedure of cardiac tumor to provide better outcomes for long-term survival rate without any recurrences. A three-dimensional thermo-electric energy model is employed to investigate nanothermal field and ablation efficiency into the left atrium tumor. The cell death model is adopted to quantify the degree of tissue injury while injecting the Fe3O4 nanoparticles concentrations up to 20% into the target tissue. The results reveal that when nanothermal field extents as a function of tissue depth (10 mm) from the electrode tip, the increasing thermal rates were approximately 0.54362%, 3.17039%, and 7.27397% for the particle concentration levels of 7%, 10%, and 15% compared with no-particle case. In the 7% Fe3O4 nanoparticles, 100% fractional damage index is achieved after ablation time of 18 s whereas tissue annihilation approach proceeds longer to complete for no-particle case. The outcomes indicate that injecting nanoparticles may lessen ablation time in surgeries and prevent damage to adjacent healthy tissue.
摘要：
射频消融是通过加热根除癌细胞或非癌细胞的名义上的侵入性技术。然而,由于不适当的射频强度不会完全消除肿瘤组织，因此仍然阻碍了成功的细胞破坏过程，导致治疗失败。在这项研究中,我们熟悉心脏肿瘤的纳米辅助射频消融术,可以为长期生存率提供更好的结果,而不会出现任何复发.采用三维热电能模型研究纳米热场和左心房肿瘤的消融效率。当将浓度高达20%的Fe3O4纳米颗粒注入靶组织时,采用细胞死亡模型来量化组织损伤的程度。结果表明，当纳米热场作为距电极尖端的组织深度（10mm）的函数延伸时，增加的热速率约为0.54362%，3.17039%,和7.27397%的颗粒浓度水平，10%,与无颗粒情况相比，为15%。在7%的Fe3O4纳米粒子中，在18s的消融时间后达到100%的部分损伤指数,而对于无颗粒的情况,组织湮没方法进行更长的时间才能完成。结果表明，注射纳米颗粒可以减少手术中的消融时间，并防止对相邻健康组织的损害。
