Abstract：
The clinical application of random flaps in wound repair has been a topic of discussion. Random flaps are prone to necrosis due to the lack of well-defined vascular blood supply during transfer surgery. Their clinical utility is restricted, financial and psychological burdens is imposed on patients due to this limitation. The survival of random skin flaps depends on factors such as ischemia-reperfusion injury, oxidative stress, local inflammatory response, and neovascularization. This review aims to provide an overview of the evidence supporting the use of random flaps in clinical practice. In addition, this review explores the impact of different medications on signaling pathways within the flap\'s local microcirculation and investigates the interconnections between these pathways.
摘要：
随机皮瓣在创面修复中的临床应用一直是研讨的课题。由于在转移手术过程中缺乏明确的血管供血，随机皮瓣容易坏死。他们的临床应用受到限制，由于这种限制，给患者带来了经济和心理负担。随机皮瓣的存活取决于缺血再灌注损伤等因素,氧化应激，局部炎症反应，和新血管形成。这篇综述旨在概述支持在临床实践中使用随机皮瓣的证据。此外,这篇综述探讨了不同药物对皮瓣局部微循环内信号通路的影响，并研究了这些通路之间的相互联系。
