Abstract：
This pilot study aimed to investigate genetic factors that may have contributed to the milder clinical outcomes of COVID-19 in Brazilian indigenous populations. 263 Indigenous from the Araweté, Kararaô, Parakanã, Xikrin do Bacajá, Kayapó and Munduruku peoples were analyzed, 55.2% women, ages ranging from 10 to 95 years (average 49.5 ± 20.7). Variants in genes involved in the entry of SARS-CoV-2 into the host cell (ACE1 rs1799752 I/D, ACE2 rs2285666 C/T, ACE2 rs73635825 A/G and TMPRSS2 rs123297605 C/T), were genotyped in indigenous peoples from the Brazilian Amazon, treated during the SARS-CoV-2 pandemic between 2020 and 2021. The distribution of genotypes did not show any association with the presence or absence of IgG antibodies. Additionally, the influence of genetic variations on the severity of the disease was not examined extensively because a significant number of indigenous individuals experienced the disease with either mild symptoms or no symptoms. It is worth noting that the frequencies of risk alleles were found to be lower in Indigenous populations compared to both continental populations and Brazilians. Indigenous Brazilian Amazon people exhibited an ethnic-specific genetic profile that may be associated with a milder disease, which could explain the unexpected response they demonstrated to COVID-19, being less impacted than Brazilians.
摘要：
这项初步研究旨在调查可能导致COVID-19在巴西土著居民中更温和的临床结果的遗传因素。263名来自阿拉韦的土著，卡拉，Parakanã,XikrindoBacajá,对Kayapó和Munduruku人民进行了分析，55.2%的女性，年龄从10岁到95岁（平均49.5±20.7）。SARS-CoV-2进入宿主细胞的基因变异（ACE1rs1799752I/D，ACE2rs2285666C/T,ACE2rs73635825A/G和TMPRSS2rs123297605C/T），在巴西亚马逊地区的土著人民中进行了基因分型，在2020年至2021年的SARS-CoV-2大流行期间接受治疗。基因型的分布与IgG抗体的存在或不存在没有任何关联。此外,没有广泛检查遗传变异对疾病严重程度的影响，因为相当多的土著个体经历了轻微症状或无症状的疾病。值得注意的是，与大陆人口和巴西人相比，土著人口中的风险等位基因频率较低。巴西亚马逊原住民表现出种族特异性的遗传特征，可能与轻度疾病相关，这可以解释他们对COVID-19的意外反应，受到的影响比巴西人小。
