Abstract：
In this study, the phytochemical profile of fifty olive leaves (OL) extracts from Spain, Italy, Greece, Portugal, and Morocco was characterized and their anti-cholinergic, anti-inflammatory, and antioxidant activities were evaluated. Luteolin-7-O-glucoside, isoharmnentin, and apigenin were involved in the acetylcholinesterase (AChE) inhibitory activity, while oleuropein and hydroxytyrosol showed noteworthy potential. Secoiridoids contributed to the cyclooxygenase-2 inhibitory activity and antioxidant capacity. Compounds such as oleuropein, ligstroside and luteolin-7-O-glucoside, may exert an important role in the ferric reducing antioxidant capacity. It should be also highlighted the role of hydroxytyrosol, hydroxycoumarins, and verbascoside concerning the antioxidant activity. This research provides valuable insights and confirms that specific compounds within OL extracts contribute to distinct anti-cholinergic, anti-inflammatory, and anti-oxidative effects.
摘要：
在这项研究中,来自西班牙的50片橄榄叶（OL）提取物的植物化学特征，意大利,希腊,葡萄牙,摩洛哥的特点是他们的抗胆碱能，抗炎,并对抗氧化活性进行了评价。木犀草素-7-O-葡萄糖苷,isoharmnentin,芹菜素参与乙酰胆碱酯酶（AChE）抑制活性，而橄榄苦苷和羟基酪醇显示出值得注意的潜力。Secoildoids有助于环氧合酶2抑制活性和抗氧化能力。化合物如橄榄苦苷，Ligstroside和木犀草素-7-O-葡萄糖苷，可能在三价铁降低抗氧化能力方面发挥重要作用。还应该强调羟基酪醇的作用，羟基香豆素,和天花苷有关抗氧化活性。这项研究提供了有价值的见解，并证实OL提取物中的特定化合物有助于独特的抗胆碱能，抗炎,和抗氧化作用。
