Abstract：
Background: Tuberculosis (TB) is a chronic, zoonotic infectious disease caused by Mycobacterium tuberculosis that infects not only humans but also animals such as pigs, cows, buffaloes, sheep, and goats. Among them, pigs are one of the main food animals in the world. If pigs are infected with M. tuberculosis, meat products will be negatively affected, causing economic losses to the livestock industry. There is currently no systematic epidemiological assessment of swine TB in the world, so it is important to know the prevalence of swine, and these data are currently lacking, so we performed a statistical analysis. Results: We searched 6791 articles and finally included data from 35,303 pigs from 15 countries or territories, showing a combined prevalence of TB in pigs of 12.1% (95% confidence interval [CI]: 9.2 to 15.9). Among them, the prevalence rate of swine TB in Europe was 15.2% (95% CI: 11.1 to 20.7, 2491/25,050), which was higher compared with other continents, and the difference was significant; the positive rate of PCR method was higher in the detection method subgroup, which was 15.7% (95% CI: 8.0 to 31.0, 376/2261); Mycobacterium bovis was detected in pigs in the M. tuberculosis typing group (9.5%, 95% CI: 6.7 to 13.5, 1364/21,430). The positive rate is higher compared with Mycobacterium capris. Conclusion: This systematic review and meta-analysis is the first to determine the global prevalence of TB in swine herds. Although the seroprevalence of swine TB in this article is very low, the harm of TB cannot be ignored. It is important to take effective control and preventive measures to stop the spread of TB to reduce the impact of diseased pigs on animal husbandry and human health.
摘要：
背景:结核病(TB)是一种慢性,由结核分枝杆菌引起的人畜共患传染病，不仅感染人类，还感染猪等动物，奶牛,水牛,绵羊,还有山羊.其中,猪是世界上主要的食用动物之一。如果猪感染了结核分枝杆菌，肉类产品将受到负面影响，给畜牧业造成经济损失。目前世界上还没有对猪结核病进行系统的流行病学评估,所以了解猪的流行程度很重要，目前缺乏这些数据，所以我们进行了统计分析。结果：我们检索了6791篇文章，最终纳入了来自15个国家或地区的35,303头猪的数据，显示猪的结核病综合患病率为12.1%(95%置信区间[CI]:9.2至15.9)。其中,欧洲猪结核病的患病率为15.2%（95%CI：11.1至20.7,2491/25,050），与其他大陆相比更高，检测方法亚组PCR法阳性率较高,为15.7%（95%CI：8.0至31.0，376/2261）；在结核分枝杆菌分型组的猪中检测到牛分枝杆菌（9.5%，95%CI：6.7至13.5，1364/21,430）。其阳性率较辣椒分枝杆菌高。结论：本系统评价和荟萃分析首次确定了猪群中结核病的全球流行情况。尽管本文中猪结核病的血清阳性率非常低，结核病的危害不容忽视。采取有效的控制和预防措施,阻止结核病的传播,减少病猪对畜牧业和人类健康的影响。
