Abstract:
The recent increase in fungal infections is a health crisis. This surge is directly tied to the increase in immunocompromised people caused by changes in medical practice, such as the use of harsh chemotherapy and immunosuppressive medicines. Immunosuppressive disorders such as HIV have exacerbated the situation dramatically. Subcutaneous or superficial fungal infections can harm the skin, keratinous tissues, and mucous membranes. This category includes some of the most common skin disorders that impact millions of people worldwide. Despite the fact that they are seldom fatal, they can have a catastrophic impact on a person\'s quality of life and, in rare situations, spread to other people or become obtrusive. The majority of fungal infections under the skin and on the surface are simply and quickly cured. An opportunistic organism that preys on a weak host or a natural intruder can both result in systemic fungal infections. Furthermore, it might be exceedingly lethal and dangerous to one\'s life. Dimorphic fungi may pose a hazard to healthy populations that are not exposed to endemic fungi. Increased surveillance, the availability of quick, noninvasive diagnostic tests, monitoring the emergence of antifungal medication resistance, and research on the pathophysiology, prevention, and management of fungal infections are just a few potential solutions to these new health problems. The goal of this review is to summarize the data available for fungal infections and the different therapies which are involved in their treatment. Additionally, it also summarizes the molecular and scientific data of the plants which contain anti-fungal activity. Data are acquired using Google, PubMed, Scholar, and other online sources.
摘要:
最近真菌感染的增加是健康危机。这种激增与医疗实践变化引起的免疫功能低下人群的增加直接相关,例如使用苛刻的化疗和免疫抑制药物。诸如HIV之类的免疫抑制疾病使情况急剧恶化。皮下或浅表真菌感染会伤害皮肤,角质组织,和粘膜。此类别包括影响全球数百万人的一些最常见的皮肤病。尽管它们很少致命,它们会对一个人的生活质量产生灾难性的影响,在罕见的情况下,传播给其他人或变得突兀。皮肤下和表面的大多数真菌感染都可以简单而迅速地治愈。捕食弱宿主或自然入侵者的机会生物都可能导致全身性真菌感染。此外,这对一个人的生命可能非常致命和危险。异形真菌可能对未暴露于地方性真菌的健康人群构成危害。加强监控,快速的可用性,非侵入性诊断测试,监测抗真菌药物耐药性的出现,和病理生理学的研究,预防,和真菌感染的管理只是这些新的健康问题的一些潜在的解决方案。这篇综述的目的是总结真菌感染的可用数据以及涉及其治疗的不同疗法。此外,它还总结了具有抗真菌活性的植物的分子和科学数据。数据是通过谷歌获得的,PubMed,学者,和其他在线来源。