PDF(Pubmed)
Abstract：
UNASSIGNED: Cell adhesion molecules (CAMs) are found on the surface of all cells, where they allow dynamic processes to take place. These include cadherins, integrins, selectins and Immunoglobulin superfamily. Directly associated with β-integrin tails is a multidomain protein known as paxillin. However, CAMs participate in cell-cell and extracellular matrix-cell interactions during histomorphogenesis in the various phases of odontogenesis. Some tumours or cysts like ameloblastoma (AB) or odontogenic keratocyst (OKC) having odontogenic origin show disturbance in the interaction of these CAMs. Hence, the assessment of paxillin expression in AB and OKC was carried out.
UNASSIGNED: The present observational study comprised 30 clinically and histologically confirmed cases of AB and OKC. All the slides were stained immunohistochemically using a paxillin antibody.
UNASSIGNED: Upon comparison of staining intensity of paxillin among AB and OKC showed statistically significant result, whereas quantitative staining and final summation showed non-significant result. Gender-wise comparison of paxillin staining intensity, quantitative staining and final summation among OKC showed significant result; however, in AB, staining intensity showed non-significant result, whereas quantitative staining and final summation showed significant result.
UNASSIGNED: Paxillin has the greatest influence on tissue morphogenesis and development. The regulation of cell mobility is aided by the multiple roles that paxillin plays in a range of cells and tissues. However, further studies using a large sample size, along with other molecular analytical methods, may be essential to draw a definite conclusion about the association of paxillin and its exact function in OKC and AB.
UNASSIGNED: The present observational study comprised 30 clinically and histologically confirmed cases of AB and OKC. All the slides were stained immunohistochemically using a paxillin antibody.
UNASSIGNED: Upon comparison of staining intensity of paxillin among AB and OKC showed statistically significant result, whereas quantitative staining and final summation showed non-significant result. Gender-wise comparison of paxillin staining intensity, quantitative staining and final summation among OKC showed significant result; however, in AB, staining intensity showed non-significant result, whereas quantitative staining and final summation showed significant result.
UNASSIGNED: Paxillin has the greatest influence on tissue morphogenesis and development. The regulation of cell mobility is aided by the multiple roles that paxillin plays in a range of cells and tissues. However, further studies using a large sample size, along with other molecular analytical methods, may be essential to draw a definite conclusion about the association of paxillin and its exact function in OKC and AB.
摘要：
■在所有细胞的表面上都发现了细胞粘附分子（CAM），它们允许动态过程发生。这些包括钙黏着蛋白，整合素,选择素和免疫球蛋白超家族。与β-整合素尾巴直接相关的是称为桩蛋白的多结构域蛋白。然而,在牙本质发生的各个阶段，CAM参与组织形态发生过程中的细胞-细胞和细胞外基质-细胞相互作用。一些肿瘤或囊肿，如成釉细胞瘤（AB）或牙源性角化囊肿（OKC），具有牙源性起源，显示这些CAM的相互作用受到干扰。因此，进行了Paxillin在AB和OKC中的表达评估。
■本观察性研究包括30例临床和组织学证实的AB和OKC病例。使用桩蛋白抗体对所有载玻片进行免疫组织化学染色。
■比较AB和OKC中的桩蛋白染色强度后显示出统计学上的显着结果，而定量染色和最终求和显示结果不显著。paxillin染色强度的性别比较，OKC的定量染色和最终求和显示出显著的结果；然而，在AB中,染色强度显示无显著结果，而定量染色和最终求和显示出显著的结果。
■Paxillin对组织形态发生和发育的影响最大。paxillin在一系列细胞和组织中发挥的多种作用有助于细胞移动性的调节。然而,使用大样本量的进一步研究，以及其他分子分析方法，对于得出有关paxillin的关联及其在OKC和AB中的确切功能的明确结论可能至关重要。
■本观察性研究包括30例临床和组织学证实的AB和OKC病例。使用桩蛋白抗体对所有载玻片进行免疫组织化学染色。
■比较AB和OKC中的桩蛋白染色强度后显示出统计学上的显着结果，而定量染色和最终求和显示结果不显著。paxillin染色强度的性别比较，OKC的定量染色和最终求和显示出显著的结果；然而，在AB中,染色强度显示无显著结果，而定量染色和最终求和显示出显著的结果。
■Paxillin对组织形态发生和发育的影响最大。paxillin在一系列细胞和组织中发挥的多种作用有助于细胞移动性的调节。然而,使用大样本量的进一步研究，以及其他分子分析方法，对于得出有关paxillin的关联及其在OKC和AB中的确切功能的明确结论可能至关重要。
