PDF(Pubmed)
Abstract：
Pancreatic cancer, one of the most fatal types of human cancers, includes several non-epithelial and stromal components, such as activated fibroblasts, vascular cells, neural cells and immune cells, that are involved in different cancers. Vascular endothelial cell growth factor 165 receptors 1 [neuropilin-1 (NRP-1)] and 2 (NRP-2) play a role in the biological behaviors of pancreatic cancer and may appear as potential therapeutic targets. The NRP family of proteins serve as co-receptors for vascular endothelial growth factor, transforming growth factor β, hepatocyte growth factor, fibroblast growth factor, semaphorin 3, epidermal growth factor, insulin-like growth factor and platelet-derived growth factor. Investigations of mechanisms that involve the NRP family of proteins may help develop novel approaches for overcoming therapy resistance in pancreatic cancer. The present review aimed to provide an in-depth exploration of the multifaceted roles of the NRP family of proteins in pancreatic cancer, including recent findings from single-cell analysis conducted within the context of pancreatic adenocarcinoma, which revealed the intricate involvement of NRP proteins at the cellular level. Through these efforts, the present study endeavored to further reveal their relationships with different biological processes and their potential as therapeutic targets in various treatment modalities, offering novel perspectives and directions for the treatment of pancreatic cancer.
摘要：
胰腺癌,人类最致命的癌症之一，包括几种非上皮和基质成分，如激活的成纤维细胞，血管细胞,神经细胞和免疫细胞，涉及不同的癌症。血管内皮细胞生长因子165受体1[神经纤毛蛋白-1（NRP-1）]和2（NRP-2）在胰腺癌的生物学行为中起作用，可能是潜在的治疗靶点。NRP蛋白家族作为血管内皮生长因子的共受体,转化生长因子β，肝细胞生长因子，成纤维细胞生长因子,信号素3,表皮生长因子,胰岛素样生长因子和血小板源性生长因子。对涉及NRP蛋白家族的机制的研究可能有助于开发克服胰腺癌治疗耐药性的新方法。本综述旨在深入探讨NRP家族蛋白在胰腺癌中的多方面作用。包括在胰腺腺癌背景下进行的单细胞分析的最新发现，这揭示了NRP蛋白在细胞水平上的复杂参与。通过这些努力,本研究努力进一步揭示它们与不同生物过程的关系，以及它们在各种治疗方式中作为治疗靶点的潜力，为胰腺癌的治疗提供了新的视角和方向。
