PDF(Pubmed)
Abstract：
An eleven-year-old Pit Bull Terrier was presented to the veterinary practice with an acute onset of whole-body seizures. The clinical signs developed in a garden where the dog was kept that morning. There was a suspicion of tremorgenic mycotoxin poisoning by compost as the dog had vomited parts of compost right before the onset of the seizures and there was a pile of compost located in the garden. The dog underwent immediate decontamination following supportive treatment and recovered fully within 24 h of intensive care. The samples of the vomit and parts of the compost were cultivated. In the sample of the vomit, Penicillium sp. was found. Subsequently, tremorgenic mycotoxins paxilline, penitrem A and roquefortine C were determined chromatographically at significant concentrations in the vomit and a growth medium with cultivated Penicillium sp. The aim of this work is to describe the complex therapeutic and diagnostic approach to the patient with a suspected tremorgenic mycotoxin poisoning where a combination of mycological and chromatographic analyses was used to confirm the diagnosis. To the best of our knowledge, this is the first confirmed case of canine tremorgenic mycotoxicosis in the Czech Republic and the first reported case of paxilline poisoning in a dog.
摘要：
一只11岁的斗牛犬因全身癫痫发作而被送往兽医实践。临床症状出现在那天早上饲养狗的花园里。怀疑是堆肥引起的霉菌毒素中毒，因为狗在癫痫发作之前就呕吐了堆肥的一部分，并且花园里有一堆堆肥。狗在支持性治疗后立即进行了去污，并在重症监护24小时内完全康复。培养呕吐物的样品和堆肥的部分。在呕吐物的样本中，青霉。找到了。随后，致幻性真菌毒素帕索林，通过色谱法测定penitremA和roquefortineC在呕吐物和培养的青霉菌的生长培养基中的显着浓度。这项工作的目的是描述对疑似震颤性霉菌毒素中毒患者的复杂治疗和诊断方法，其中使用了真菌学和色谱分析的组合来确认诊断。据我们所知,这是捷克共和国首例确诊的犬震性真菌中毒病例，也是首例报道的犬中paxilline中毒病例。
