PDF(Pubmed)
Abstract：
BACKGROUND: A novel approach known as intraosseous regional administration (IORA) has emerged as a technique for delivering prophylactic antibiotics, and it results in higher tissue concentrations around the knee. It is hypothesized that IORA of cefazolin for antibiotic prophylaxis during total knee arthroplasty will result in sustained effective levels for a longer duration. The aim of the current study was to investigate temporal changes in peri-knee cefazolin blood concentrations after IORA of cefazolin.
METHODS: Twelve rabbits were randomly divided into two groups, with six rabbits in each group. In control group a single intravenous bolus injection of cefazolin (10 mL, 100 mg) was administered into the marginal ear vein. In experimental groupexperimental group the same dose of cefazolin was injected into the left tibial marrow cavity after tourniquet inflation at the base of the left thigh. Blood samples were collected periodically at different timepoints, and cefazolin concentrations were determined.
RESULTS: The intraosseous treatment resulted in significant differences in plasma cefazolin concentrations at all timepoints. Experimental group exhibited higher plasma cefazolin concentrations than control group.
CONCLUSIONS: Cefazolin in intraosseous regional prophylaxis exhibits effectiveness in intraoperative antibiotic prophylaxis by maintaining concentrations above the minimum inhibitory concentration for extended durations, rather than relying solely on high concentrations.
METHODS: Twelve rabbits were randomly divided into two groups, with six rabbits in each group. In control group a single intravenous bolus injection of cefazolin (10 mL, 100 mg) was administered into the marginal ear vein. In experimental groupexperimental group the same dose of cefazolin was injected into the left tibial marrow cavity after tourniquet inflation at the base of the left thigh. Blood samples were collected periodically at different timepoints, and cefazolin concentrations were determined.
RESULTS: The intraosseous treatment resulted in significant differences in plasma cefazolin concentrations at all timepoints. Experimental group exhibited higher plasma cefazolin concentrations than control group.
CONCLUSIONS: Cefazolin in intraosseous regional prophylaxis exhibits effectiveness in intraoperative antibiotic prophylaxis by maintaining concentrations above the minimum inhibitory concentration for extended durations, rather than relying solely on high concentrations.
摘要：
背景：一种称为骨内区域给药（IORA）的新方法已经成为一种提供预防性抗生素的技术，会导致膝盖周围组织浓度升高。假设在全膝关节置换术期间用于抗生素预防的头孢唑啉的IORA将导致在更长的持续时间内持续有效水平。本研究的目的是研究头孢唑啉IORA后膝关节周围血药浓度的时间变化。
方法:12只家兔随机分为两组,每组六只兔子。对照组单次静脉推注头孢唑啉(10mL，100mg）被施用到边缘耳静脉中。在实验组中，在左大腿底部充注止血带后，将相同剂量的头孢唑林注射到左胫骨骨髓腔中。在不同的时间点定期收集血样，并测定头孢唑啉浓度。
结果:骨内处理导致在所有时间点血浆头孢唑啉浓度的显著差异。实验组血浆头孢唑啉浓度高于对照组。
结论：头孢唑啉在骨内区域预防中表现出有效的术中抗生素预防，通过将浓度维持在最低抑制浓度以上延长持续时间，而不是仅仅依靠高浓度。
方法:12只家兔随机分为两组,每组六只兔子。对照组单次静脉推注头孢唑啉(10mL，100mg）被施用到边缘耳静脉中。在实验组中，在左大腿底部充注止血带后，将相同剂量的头孢唑林注射到左胫骨骨髓腔中。在不同的时间点定期收集血样，并测定头孢唑啉浓度。
结果:骨内处理导致在所有时间点血浆头孢唑啉浓度的显著差异。实验组血浆头孢唑啉浓度高于对照组。
结论：头孢唑啉在骨内区域预防中表现出有效的术中抗生素预防，通过将浓度维持在最低抑制浓度以上延长持续时间，而不是仅仅依靠高浓度。
