METHODS: Twelve rabbits were randomly divided into two groups, with six rabbits in each group. In control group a single intravenous bolus injection of cefazolin (10 mL, 100 mg) was administered into the marginal ear vein. In experimental groupexperimental group the same dose of cefazolin was injected into the left tibial marrow cavity after tourniquet inflation at the base of the left thigh. Blood samples were collected periodically at different timepoints, and cefazolin concentrations were determined.
RESULTS: The intraosseous treatment resulted in significant differences in plasma cefazolin concentrations at all timepoints. Experimental group exhibited higher plasma cefazolin concentrations than control group.
CONCLUSIONS: Cefazolin in intraosseous regional prophylaxis exhibits effectiveness in intraoperative antibiotic prophylaxis by maintaining concentrations above the minimum inhibitory concentration for extended durations, rather than relying solely on high concentrations.
方法:12只家兔随机分为两组,每组六只兔子。对照组单次静脉推注头孢唑啉(10mL,100mg)被施用到边缘耳静脉中。在实验组中,在左大腿底部充注止血带后,将相同剂量的头孢唑林注射到左胫骨骨髓腔中。在不同的时间点定期收集血样,并测定头孢唑啉浓度。
结果:骨内处理导致在所有时间点血浆头孢唑啉浓度的显著差异。实验组血浆头孢唑啉浓度高于对照组。
结论:头孢唑啉在骨内区域预防中表现出有效的术中抗生素预防,通过将浓度维持在最低抑制浓度以上延长持续时间,而不是仅仅依靠高浓度。