关键词: Drug Substitution EVIDENCE-BASED MEDICINE Organization and Administration PEDIATRICS PHARMACEUTICAL PREPARATIONS PUBLIC HEALTH Quality Assurance, Health Care Quality of Health Care Safety

来  源:   DOI:10.1136/ejhpharm-2023-004032

Abstract:
Medicine shortages, especially those involving antibiotics, pose a global public health dilemma that can lead to adverse health outcomes. The aim of this study was to assess the supply situation of various antimicrobials in liquid dosage forms, which represent the mainstay of therapy for paediatric infections. The availability was examined over a period of 27 weeks in Austria. During the time period investigated, 34 products (81.0%) were not available for over 50% of the time; eight of those (19.0%) experienced complete unavailability. Only four products (9.5%) demonstrated continuous availability. Regarding penicillin antibiotics, amoxicillin was not available for 77.8% of the time (21 weeks) and amoxicillin/clavulanic acid for 59.3% (16 weeks). Regular monitoring of availability status can help mitigate this issue; however, cross-national strategies are urgently needed to guarantee a constant supply in the future.
摘要:
药品短缺,尤其是那些涉及抗生素的,构成全球公共卫生困境,可能导致不良健康结果。本研究的目的是评估液体剂型中各种抗菌剂的供应情况,这是儿科感染治疗的主要方法。在奥地利,对可用性进行了27周的检查。在调查期间,34种产品(81.0%)在超过50%的时间内不可用;其中8种(19.0%)完全不可用。只有四种产品(9.5%)表现出持续可用性。关于青霉素抗生素,有77.8%的时间(21周)没有阿莫西林,有59.3%的时间(16周)没有阿莫西林/克拉维酸.定期监视可用性状态可以帮助缓解此问题;但是,迫切需要跨国战略来保证未来的持续供应。
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