OBJECTIVE: This study investigates the therapeutic potential of SGR (a Chinese medicine) in psoriasis and its impact on T cell differentiation.
METHODS: An integrated network pharmacology and bioinformatics approach was employed to elucidate the mechanisms of SGR in regulating T cell differentiation. A psoriasis mouse model was utilized to evaluate the effects of SGR on T cell subsets. Immunohistochemistry and gene expression analyses were conducted to investigate the modulation of insulin receptor signaling pathways by SGR.
RESULTS: SGR treatment effectively reset the expression of various T cell subsets in the psoriasis mouse model, suggesting its ability to regulate T cell differentiation and immune function. Furthermore, SGR treatment inhibited insulin receptor signaling and downstream pathways, including PI3K/AKT and ERK, in psoriatic skin lesions. This indicates that SGR may exert its therapeutic effects through modulation of the insulin receptor signaling pathway.
CONCLUSIONS: This study provides novel insights into the therapeutic potential of SGR in psoriasis. By modulating T cell differentiation and targeting the insulin receptor signaling pathway, SGR holds promise as a potential treatment option for psoriasis.
目的:本研究探讨SGR(中药)在银屑病中的治疗潜力及其对T细胞分化的影响。
方法:采用整合的网络药理学和生物信息学方法阐明SGR调节T细胞分化的机制。使用牛皮癣小鼠模型来评估SGR对T细胞亚群的影响。进行免疫组织化学和基因表达分析以研究SGR对胰岛素受体信号通路的调节。
结果:SGR治疗可有效重置银屑病小鼠模型中各种T细胞亚群的表达,提示其调节T细胞分化和免疫功能的能力。此外,SGR治疗抑制胰岛素受体信号和下游通路,包括PI3K/AKT和ERK,牛皮癣皮肤病变。这表明SGR可能通过调节胰岛素受体信号通路发挥其治疗作用。
结论:这项研究为SGR在银屑病中的治疗潜力提供了新的见解。通过调节T细胞分化和靶向胰岛素受体信号通路,SGR有望成为牛皮癣的潜在治疗选择。