Abstract：
BACKGROUND: The urine protein to creatinine ratio (UPCR) correlates well with the 24-h urine protein test (24-h UPT) and is a reliable indicator of proteinuria. However, in nephrotic syndrome, the correlation between the UPCR and the 24-h UPT tends to decrease. To address this, we introduced the fractional excretion of total protein (FETP), which reflects serum total protein and creatinine levels because severe hypoproteinemia and/or elevated serum creatinine levels tend to occur under these conditions. The 24-h UPT corrected for body surface area (BSA) (24-h UPT/BSA) was used to take body size into consideration. The correlation coefficients for 24-h UPT/BSA and FETP and 24-h UPT/BSA and UPCR were calculated. The statistical significance of the differences between these coefficients was also calculated.
METHODS: Thirty-six pediatric patients with nephrotic syndrome were included in this study. The FETP was calculated as total protein clearance/creatinine clearance (%). Correlation coefficients were calculated for 24-h UPT/BSA and FETP and 24-h UPT/BSA and UPCR. The statistical significance of the differences between these coefficients was also calculated.
RESULTS: The mean ± standard error of FETP was 0.11% ± 0.013%. The correlation coefficients of FETP and UPCR with 24-h UPT/BSA were 0.91 and 0.81, respectively. The FETP demonstrated a significantly stronger correlation with 24-h UPT/BSA than with UPCR (p = 0.01).
CONCLUSIONS: The FETP correlated more strongly with 24-h UPT/BSA than with UPCR in patients with nephrotic syndrome. The FETP is a reliable indicator of proteinuria in nephrotic syndrome, especially in patients with severe hypoproteinemia or elevated serum creatinine levels.
METHODS: Thirty-six pediatric patients with nephrotic syndrome were included in this study. The FETP was calculated as total protein clearance/creatinine clearance (%). Correlation coefficients were calculated for 24-h UPT/BSA and FETP and 24-h UPT/BSA and UPCR. The statistical significance of the differences between these coefficients was also calculated.
RESULTS: The mean ± standard error of FETP was 0.11% ± 0.013%. The correlation coefficients of FETP and UPCR with 24-h UPT/BSA were 0.91 and 0.81, respectively. The FETP demonstrated a significantly stronger correlation with 24-h UPT/BSA than with UPCR (p = 0.01).
CONCLUSIONS: The FETP correlated more strongly with 24-h UPT/BSA than with UPCR in patients with nephrotic syndrome. The FETP is a reliable indicator of proteinuria in nephrotic syndrome, especially in patients with severe hypoproteinemia or elevated serum creatinine levels.
摘要：
背景：尿蛋白肌酐比（UPCR）与24小时尿蛋白检测（24小时UPT）密切相关，是蛋白尿的可靠指标。然而,在肾病综合征中，UPCR和24小时UPT之间的相关性趋于降低。为了解决这个问题，我们介绍了总蛋白的排泄分数（FETP），这反映了血清总蛋白和肌酐水平，因为在这些情况下往往会发生严重的低蛋白血症和/或血清肌酐水平升高。使用针对体表面积（BSA）校正的24小时UPT（24小时UPT/BSA）来考虑身体大小。计算24小时UPT/BSA和FETP以及24小时UPT/BSA和UPCR的相关系数。还计算了这些系数之间差异的统计显著性。
方法：本研究纳入36例肾病综合征患儿。FETP计算为总蛋白清除率/肌酐清除率(%)。计算24小时UPT/BSA和FETP以及24小时UPT/BSA和UPCR的相关系数。还计算了这些系数之间差异的统计显著性。
结果：FETP的平均值±标准误差为0.11%±0.013%。FETP和UPCR与24hUPT/BSA的相关系数分别为0.91和0.81。FETP与24小时UPT/BSA的相关性明显强于UPCR（p=0.01）。
结论：在肾病综合征患者中，FETP与24小时UPT/BSA的相关性比与UPCR的相关性更强。FETP是肾病综合征蛋白尿的可靠指标，尤其是严重低蛋白血症或血清肌酐水平升高的患者。
方法：本研究纳入36例肾病综合征患儿。FETP计算为总蛋白清除率/肌酐清除率(%)。计算24小时UPT/BSA和FETP以及24小时UPT/BSA和UPCR的相关系数。还计算了这些系数之间差异的统计显著性。
结果：FETP的平均值±标准误差为0.11%±0.013%。FETP和UPCR与24hUPT/BSA的相关系数分别为0.91和0.81。FETP与24小时UPT/BSA的相关性明显强于UPCR（p=0.01）。
结论：在肾病综合征患者中，FETP与24小时UPT/BSA的相关性比与UPCR的相关性更强。FETP是肾病综合征蛋白尿的可靠指标，尤其是严重低蛋白血症或血清肌酐水平升高的患者。
