PDF(Pubmed)
Abstract：
Chronic inflammatory conditions, such as juvenile idiopathic arthritis, are associated with growth failure. Growth failure appears to be correlated with both the effects of inflammation and negative effects of glucocorticoids (used as therapeutic option) on the growth hormone axis and locally on the growth plate and bone metabolism. In the last decade, the introduction of biologics has changed the disease course regarding consequences and outcomes. Anyway in some cases, treatment with biologics has failed in restoring normal growth in patients with juvenile idiopathic arthritis; in contrast, several studies have reported improved height velocity and growth rate in patients with juvenile idiopathic arthritis treated with growth hormone. This study aimed to evaluate the impact of growth hormone treatment on the growth and pubertal development in juvenile idiopathic arthritis patients through a narrative review of the literature over the last four decades.
摘要：
慢性炎症，比如幼年特发性关节炎，与成长失败有关。生长失败似乎与炎症的影响以及糖皮质激素（用作治疗选择）对生长激素轴以及局部生长板和骨代谢的负面影响有关。在过去的十年里，生物制剂的引入改变了疾病在后果和结局方面的病程.无论如何，在某些情况下，生物制剂治疗未能恢复幼年特发性关节炎患者的正常生长；相比之下，有几项研究报道，使用生长激素治疗的幼年特发性关节炎患者的身高速度和生长速度均有改善。本研究旨在通过对过去四十年的文献进行叙述性回顾，评估生长激素治疗对幼年特发性关节炎患者生长和青春期发育的影响。
