PDF(Pubmed)
Abstract：
With the coverage of COVID-19 vaccination, it has been possible to observe the potential side effects of SARS-CoV-2 vaccines, with the most common ones being fever, myalgia, headache, and fatigue. However, an association has been observed between new and recurrent kidney injuries, mainly glomerulonephritis and lupus nephritis associated with ANCA, with the Pfizer-BioNTech, Moderna, Sinovac, and AstraZeneca vaccines, although the relationship between them is not clear. We report a case of ANCA-related vasculitis and lupus glomerulonephritis after the second dose of the AstraZeneca vaccine. The elderly patient presented significant worsening of kidney function after immunosuppression and complications after a new onset COVID-19 infection that led to death. We provide a literature review about kidney damage related to ANCA vasculitis after COVID-19 vaccine, aiming for a better understanding of the pathophysiological mechanism of kidney injury, its presentation, and treatment.
摘要：
随着COVID-19疫苗的覆盖，已经有可能观察到SARS-CoV-2疫苗的潜在副作用，最常见的是发烧，肌痛，头痛,和疲劳。然而,已经观察到新的和复发性肾损伤之间的关联，主要是与ANCA相关的肾小球肾炎和狼疮性肾炎，辉瑞生物技术公司,Moderna,Sinovac,和阿斯利康疫苗，虽然它们之间的关系并不清楚。我们报告了第二剂阿斯利康疫苗后，ANCA相关血管炎和狼疮性肾小球肾炎的病例。该老年患者在免疫抑制后肾功能明显恶化，新发COVID-19感染导致死亡后出现并发症。我们提供了关于COVID-19疫苗接种后与ANCA血管炎相关的肾脏损害的文献综述，为了更好地了解肾损伤的病理生理机制，其介绍,和治疗。
