Abstract：
Multiple aggregated yellow-white globules (MAY globules) have been recently described as dermoscopic structures of high specificity associated with high-risk non-pigmented basal cell carcinoma (BCC). To evaluate the diagnostic accuracy of MAY globules in a cohort of pigmented and non-pigmented BCC of all histological types. This was a retrospective case-control study. Dermoscopic and clinical images were all histopathologically confirmed as BCCs of patients seen consecutively at dermatology consultation. Control cases were benign or malignant tumours randomly selected from the database of 8,250 patients. A total of 389 BCCs were included. MAY globules were present in 192 (49%) cases in the BCC group and in only 25 cases in the control group (6,4%). The odds ratio for the diagnosis of BCC was 14.2 (95% CI: 9.62-20.95]). The presence of MAY globules was significant in three histological subtypes, including superficial BCCs. This study shows that MAY globules are a major dermoscopic sign for the diagnosis of BCC, regardless of their histological subtype and their pigmentation.
摘要：
多个聚集的黄白色小球（MAY小球）最近被描述为与高风险非色素基底细胞癌（BCC）相关的高特异性皮肤镜结构。评估所有组织学类型的色素沉着和非色素沉着BCC队列中MAY小球的诊断准确性。这是一项回顾性病例对照研究。皮肤镜和临床图像均在组织病理学上证实为在皮肤科咨询中连续见到的患者的BCC。对照病例是从8,250名患者的数据库中随机选择的良性或恶性肿瘤。共包括389个BCC。BCC组192例（49％）病例中可能存在小球，对照组仅25例（6,4％）。诊断BCC的比值比为14.2（95％CI：9.62-20.95）。MAY小球的存在在三种组织学亚型中是显著的，包括表面的BCC。这项研究表明，MAY小球是诊断BCC的主要皮肤镜标志，无论其组织学亚型和色素沉着。
