Abstract：
This article reviews the 2022 European Society for Photodynamic Therapy (Euro-PDT) Annual Congress. PDT has been investigated for the treatment of a broad number of oncologic, infectious and inflammatory indications. New studies confirm the potential for wider use of topical PDT for acne and photoaging, as well as several uncommon conditions including tinea capitis, Mycobacterium marinum, cutaneous alternariosis, resistant acral warts, eyelid Bowen\'s disease, mycosis fungoides, pseudolymphoma, and graft-versus-host disease. Hidradenitis suppurativa patients may also benefit from intra-lesional PDT. Several methods of delivering PDT have been validated, including conventional, daylight and artificial daylight PDT. Light-emitting fabrics have emerged as an innovative solution to the delivery of uniform light over the scalp as well as anatomically-challenging sites, with opportunities now to control and monitor these devices via mobile phone applications. Pre-treatment of patients with thicker, more difficult-to-treat actinic keratoses (AK) with calcitriol appears to be a practical approach to increasing efficacy, although this is associated with increased local skin reactions. Sequential treatment of AK and photoaging with daylight-PDT and injectable NASHA gel indicates that these two therapeutic approaches offer complementary effects. Potential biomarkers may help predict responsiveness of patients with field cancerization and AK receiving daylight PDT. Over-expression of the proto-oncogene, Myc, has been observed in poor responders, whilst the tumour suppressor gene, PTEN, showed under-expression. The potential for use and methods of delivery of topical PDT for dermatological indications continue to expand the enhanced choice of treatment offered to patients.
摘要：
本文回顾了2022年欧洲光动力治疗学会（Euro-PDT）年度大会。PDT已经被研究用于治疗多种肿瘤，感染和炎症指征。新的研究证实了广泛使用局部PDT治疗痤疮和光老化的潜力，以及几种罕见的疾病，包括头癣，marinum分枝杆菌,皮肤交替病，抗性肢端疣，眼睑Bowen病,霉菌病,假性淋巴瘤,和移植物抗宿主病。化脓性汗腺炎患者也可从病灶内PDT获益。已经验证了几种提供PDT的方法，包括常规的,日光和人工日光PDT。发光织物已成为一种创新的解决方案，可以在头皮以及具有解剖学挑战性的部位上提供均匀的光。现在有机会通过手机应用程序控制和监控这些设备。患者的治疗前较厚，骨化三醇治疗光化性角化病（AK）似乎是一种提高疗效的实用方法，尽管这与局部皮肤反应增加有关。用日光-PDT和可注射NASHA凝胶对AK和光老化的顺序治疗表明这两种治疗方法提供了互补的效果。潜在的生物标志物可能有助于预测接受日光PDT的田野癌变和AK患者的反应性。原癌基因的过度表达，Myc,在反应不佳的人中观察到，而肿瘤抑制基因，PTEN,显示表达不足。用于皮肤病学适应症的局部PDT的使用和递送方法的潜力继续扩大提供给患者的治疗的增强选择。
