PDF(Pubmed)
Abstract：
Parvalbumin (PV) interneurons in the auditory cortex (AC) play a crucial role in shaping auditory processing, including receptive field formation, temporal precision enhancement, and gain regulation. PV interneurons are also the primary inhibitory neurons in the tail of the striatum (TS), which is one of the major descending brain regions in the auditory nervous system. However, the specific roles of TS-PV interneurons in auditory processing remain elusive. In this study, morphological and slice recording experiments in both male and female mice revealed that TS-PV interneurons, compared with AC-PV interneurons, were present in fewer numbers but exhibited longer projection distances, which enabled them to provide sufficient inhibitory inputs to spiny projection neurons (SPNs). Furthermore, TS-PV interneurons received dense auditory input from both the AC and medial geniculate body (MGB), particularly from the MGB, which rendered their auditory responses comparable to those of AC-PV interneurons. Optogenetic manipulation experiments demonstrated that TS-PV interneurons were capable of bidirectionally regulating the auditory responses of SPNs. Our findings suggest that PV interneurons can effectively modulate auditory processing in the TS and may play a critical role in auditory-related behaviors.
摘要：
在听觉皮层（AC）中的小白蛋白（PV）中间神经元在塑造听觉处理中起着至关重要的作用，包括感受野形成，时间精度增强，并获得调节。PV中间神经元也是纹状体（TS）尾部的主要抑制性神经元，这是听觉神经系统中主要的大脑下降区域之一。然而,TS-PV中间神经元在听觉处理中的特定作用仍然难以捉摸。在这项研究中,雄性和雌性小鼠的形态学和切片记录实验表明，TS-PV中间神经元，与AC-PV中间神经元相比，数量较少，但投影距离较长，这使它们能够为多刺投射神经元(SPN)提供足够的抑制性输入。此外，TS-PV中间神经元从AC和内侧膝状体（MGB）接收密集的听觉输入，特别是来自MGB的，这使得它们的听觉反应与AC-PV中间神经元相当。光遗传学操作实验表明，TS-PV中间神经元能够双向调节SPN的听觉反应。我们的发现表明，PV中间神经元可以有效地调节TS中的听觉处理，并且可能在听觉相关行为中起关键作用。
