PDF(Pubmed)
Abstract：
The FERM domain is a conserved and widespread protein module that appeared in the common ancestor of amoebae, fungi, and animals, and is therefore now found in a wide variety of species. The primary function of the FERM domain is localizing to the plasma membrane through binding lipids and proteins of the membrane; thus, for a long time, FERM domain-containing proteins (FDCPs) were considered exclusively cytoskeletal. Although their role in the cytoplasm has been extensively studied, the recent discovery of the presence and importance of cytoskeletal proteins in the nucleus suggests that FDCPs might also play an important role in nuclear function. In this review, we collected data on their nuclear localization, transport, and possible functions, which are still scattered throughout the literature, with special regard to the role of the FERM domain in these processes. With this, we would like to draw attention to the exciting, new dimension of the role of FDCPs, their nuclear activity, which could be an interesting novel direction for future research.
摘要：
FERM结构域是一个保守和广泛的蛋白质模块，出现在变形虫的共同祖先，真菌,和动物,因此现在在各种各样的物种中发现。FERM结构域的主要功能是通过结合膜的脂质和蛋白质定位到质膜;因此，很长一段时间,含有FERM结构域的蛋白质(FDCP)被认为是唯一的细胞骨架。尽管它们在细胞质中的作用已被广泛研究，细胞骨架蛋白在细胞核中的存在和重要性的最新发现表明,FDCPs也可能在细胞核功能中发挥重要作用.在这次审查中,我们收集了它们核定位的数据，运输,和可能的功能，它们仍然分散在整个文学作品中，特别考虑FERM结构域在这些过程中的作用。有了这个,我们想提请注意令人兴奋的，FDCPs作用的新维度，他们的核活动，这可能是未来研究的一个有趣的新方向。
