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Abstract：
OBJECTIVE: To explore the correlation between polycystic ovary syndrome (PCOS) and periodontitis in light of cytokines levels, sex hormone levels and metabolism-related indicators and their changes during progression of the two diseases.
METHODS: Twenty healthy subjects and 40 patients diagnosed with PCOS underwent full-mouth periodontal examinations to obtain full-mouth plaque score (FMPS), gingival bleeding index of probing (BOP), probing depth (PD), and clinical attachment level (CAL). The participants were divided into Group A without periodontitis or PCOS (n=15), Group B with PCOS but without periodontitis (n=28), Group C with periodontitis but without PCOS (n=5), and Group D with both diseases (n=12). Serum levels of luteinizing hormone/follicle stimulating hormone (LH/FSH), testosterone, prolactin, progesterone and estradiol, and the levels of interleukin 6 (IL-6), IL-17A, tumor necrosis factor α and matrix metalloproteinase 8 (MMP-8) in both serum and saliva samples were measured at the time of enrolment and at 3 and 6 months after enrolment and compared among the 4 groups.
RESULTS: Serum MMP-8 level was significantly higher in Group B than in Group A (P<0.05). Salivary MMP-8 level was significantly higher in Group D than in Group B (P<0.05). Salivary MMP-8, LH, and LH/FSH levels and serum and salivary IL-6 and progesterone levels all tended to increase in the 6 months after enrollment (OR>1, P<0.05). During the follow-up period, serum IL-6 levels differed significantly between the non-PCOS groups (A and C) and PCOS groups (B and D)(P<0.05); serum IL-6 and salivary MMP-8 levels differed significantly between the non-periodontitis groups (A and B) and periodontitis groups (C and D)(P<0.05). Spearman correlation analysis indicated positive correlations of LH and LH/FSH with PD (P<0.05); testosterone and LH/FSH were positively correlated with serum MMP-8 levels (P<0.05), and PD, BOP and FMPS were positively correlated with salivary MMP-8 levels (P<0.01).
CONCLUSIONS: There is a correlation between PCOS and periodontitis, and their progression is accompanied by changes in serum and salivary levels of pro-inflammatory cytokines and serum sex hormones.
METHODS: Twenty healthy subjects and 40 patients diagnosed with PCOS underwent full-mouth periodontal examinations to obtain full-mouth plaque score (FMPS), gingival bleeding index of probing (BOP), probing depth (PD), and clinical attachment level (CAL). The participants were divided into Group A without periodontitis or PCOS (n=15), Group B with PCOS but without periodontitis (n=28), Group C with periodontitis but without PCOS (n=5), and Group D with both diseases (n=12). Serum levels of luteinizing hormone/follicle stimulating hormone (LH/FSH), testosterone, prolactin, progesterone and estradiol, and the levels of interleukin 6 (IL-6), IL-17A, tumor necrosis factor α and matrix metalloproteinase 8 (MMP-8) in both serum and saliva samples were measured at the time of enrolment and at 3 and 6 months after enrolment and compared among the 4 groups.
RESULTS: Serum MMP-8 level was significantly higher in Group B than in Group A (P<0.05). Salivary MMP-8 level was significantly higher in Group D than in Group B (P<0.05). Salivary MMP-8, LH, and LH/FSH levels and serum and salivary IL-6 and progesterone levels all tended to increase in the 6 months after enrollment (OR>1, P<0.05). During the follow-up period, serum IL-6 levels differed significantly between the non-PCOS groups (A and C) and PCOS groups (B and D)(P<0.05); serum IL-6 and salivary MMP-8 levels differed significantly between the non-periodontitis groups (A and B) and periodontitis groups (C and D)(P<0.05). Spearman correlation analysis indicated positive correlations of LH and LH/FSH with PD (P<0.05); testosterone and LH/FSH were positively correlated with serum MMP-8 levels (P<0.05), and PD, BOP and FMPS were positively correlated with salivary MMP-8 levels (P<0.01).
CONCLUSIONS: There is a correlation between PCOS and periodontitis, and their progression is accompanied by changes in serum and salivary levels of pro-inflammatory cytokines and serum sex hormones.
摘要：
目的:从细胞因子水平探讨多囊卵巢综合征(PCOS)与牙周炎的相关性。性激素水平和代谢相关指标及其在两种疾病进展过程中的变化。
方法：20名健康受试者和40名诊断为PCOS的患者进行全口牙周检查，以获得全口菌斑评分（FMPS），牙龈探查出血指数（BOP），探测深度(PD),和临床依恋水平（CAL）。参与者被分为A组，无牙周炎或PCOS（n=15），B组有PCOS但无牙周炎（n=28），C组有牙周炎但没有PCOS（n=5），和D组两种疾病（n=12）。血清黄体生成素/卵泡刺激素(LH/FSH)水平,睾丸激素，催乳素,孕酮和雌二醇，和白细胞介素6（IL-6）的水平，IL-17A,在入选时和入选后3个月和6个月测量血清和唾液样本中的肿瘤坏死因子α和基质金属蛋白酶8（MMP-8），并在4组之间进行比较。
结果：B组血清MMP-8水平明显高于A组（P<0.05）。D组大鼠唾液MMP-8水平明显高于B组(P<0.05)。唾液MMP-8，LH，入组后6个月，LH/FSH水平以及血清和唾液IL-6和孕酮水平均呈升高趋势（OR>1，P<0.05）。在后续期间,血清IL-6水平在非PCOS组（A和C）和PCOS组（B和D）之间存在显着差异（P<0.05）；血清IL-6和唾液MMP-8水平在非牙周炎组（A和B）和牙周炎组（C和D）之间存在显着差异（P<0.05）。Spearman相关分析显示LH、LH/FSH与PD呈正相关(P<0.05);睾酮、LH/FSH与血清MMP-8呈正相关(P<0.05)。还有PD,BOP和FMPS与唾液MMP-8水平呈正相关(P<0.01)。
结论：PCOS与牙周炎之间存在相关性，它们的进展伴随着血清和唾液中促炎细胞因子和血清性激素水平的变化。
方法：20名健康受试者和40名诊断为PCOS的患者进行全口牙周检查，以获得全口菌斑评分（FMPS），牙龈探查出血指数（BOP），探测深度(PD),和临床依恋水平（CAL）。参与者被分为A组，无牙周炎或PCOS（n=15），B组有PCOS但无牙周炎（n=28），C组有牙周炎但没有PCOS（n=5），和D组两种疾病（n=12）。血清黄体生成素/卵泡刺激素(LH/FSH)水平,睾丸激素，催乳素,孕酮和雌二醇，和白细胞介素6（IL-6）的水平，IL-17A,在入选时和入选后3个月和6个月测量血清和唾液样本中的肿瘤坏死因子α和基质金属蛋白酶8（MMP-8），并在4组之间进行比较。
结果：B组血清MMP-8水平明显高于A组（P<0.05）。D组大鼠唾液MMP-8水平明显高于B组(P<0.05)。唾液MMP-8，LH，入组后6个月，LH/FSH水平以及血清和唾液IL-6和孕酮水平均呈升高趋势（OR>1，P<0.05）。在后续期间,血清IL-6水平在非PCOS组（A和C）和PCOS组（B和D）之间存在显着差异（P<0.05）；血清IL-6和唾液MMP-8水平在非牙周炎组（A和B）和牙周炎组（C和D）之间存在显着差异（P<0.05）。Spearman相关分析显示LH、LH/FSH与PD呈正相关(P<0.05);睾酮、LH/FSH与血清MMP-8呈正相关(P<0.05)。还有PD,BOP和FMPS与唾液MMP-8水平呈正相关(P<0.01)。
结论：PCOS与牙周炎之间存在相关性，它们的进展伴随着血清和唾液中促炎细胞因子和血清性激素水平的变化。
