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Abstract：
Background: Uterine blood supply has been identified as a potential factor in implantation failure. Objective: This study aimed to investigate Doppler indices in the uterine artery, including vascular flow and resistance, as well as the amount of sub-endometrial blood supply in women with a history of repeated implantation failure (RIF) compared to the non-RIF group. Materials and Methods: This cross-sectional study was conducted with 139 women candidates for frozen embryo transfer in Yazd Reproductive Sciences Institute, Yazd, Iran from February to July 2023. Group A (n = 68) included women with a history of more than 2 RIF, and group B (n = 71) included women candidates for implantation for the first time without RIF. Doppler ultrasound indices of uterine artery and sub-endometrium, including sub-endometrial flow, uterine artery flow, uterine artery resistance, and peak systolic velocity, were recorded. Results: No significant differences were observed in uterine artery Doppler pulsatility index and peak systolic velocity between groups, but the uterine artery resistance index was significantly higher in the A group (p < 0.001). A significant difference was observed in the perfusion area between groups. 60/68 women in the group A had endometrial perfusion in areas 2 and 3 (p < 0.001). Conclusion: Our study revealed that women with RIF exhibited higher resistance index in sub-endometrial arteries compared to the non-RIF group.
摘要：
背景：子宫供血已被确定为植入失败的潜在因素。目的:探讨子宫动脉的多普勒指数,包括血管流动和阻力，以及与非RIF组相比，有反复植入失败（RIF）病史的女性的子宫内膜下血液供应量。材料和方法：这项横断面研究是在Yazd生殖科学研究所对139名进行冷冻胚胎移植的女性候选人进行的，亚兹德,伊朗从2023年2月到7月。A组（n=68）包括有超过2RIF病史的女性，B组（n=71）包括首次无RIF植入的女性候选人。子宫动脉和子宫内膜下的多普勒超声指标,包括子宫内膜下血流,子宫动脉血流,子宫动脉阻力，和峰值收缩期速度,被记录下来。结果:各组子宫动脉多普勒搏动指数和收缩期峰值血流速度差异无统计学意义,但A组子宫动脉阻力指数明显高于A组(p<0.001)。两组之间的灌注面积存在显着差异。A组中60/68名妇女在区域2和3有子宫内膜灌注(p<0.001)。结论：我们的研究表明，与非RIF组相比，患有RIF的女性子宫内膜下动脉的阻力指数更高。
