PDF(Pubmed)
Abstract：
UNASSIGNED: Cardiac surgery in Congenital Heart Disease-Heterotaxy (CHD-HTX) patients often leads to increased postoperative airway complications. Abnormal respiratory ciliary function, resembling primary ciliary dyskinesia, has been observed. We expanded the sample size by retrospectively reviewing Ciliary Dysfunction (CD) in CHD-HTX patients to verify the increased risk of post-surgical respiratory complications.
UNASSIGNED: We conducted a retrospective review of 69 CHD-HTX patients undergoing cardiac surgery, assessing abnormal respiratory function using nasal nitric oxide (nNO) levels and nasal ciliary motion observed in video microscopy. Data collected included demographics, surgical details, postoperative complications, length of stay, ICU hours, salvage procedures, intubation duration, and mortality.
UNASSIGNED: The CD and no-CD cohorts exhibited notable similarities in risk adjustment in Congenital Heart Surgery-1 (RACHS-1) risk categories, age at the time of surgery, and the duration of follow-up evaluations. We observed a trend toward an increased length of post-operative stay in the CD group (15.0 vs. 14.0; P = 0.0017). CHD-HTX patients with CD showed significantly higher rates of respiratory complications (70% vs. 44.4%; P = 0.008). There were no notable variances observed in postoperative hospitalization duration, mechanical ventilation period, or surgical mortality.
UNASSIGNED: Our findings suggest that CHD-HTX patients with CD may face an elevated risk of respiratory complications. These results offer guidance for perioperative management and serve as a reference for further pathological studies.
UNASSIGNED: We conducted a retrospective review of 69 CHD-HTX patients undergoing cardiac surgery, assessing abnormal respiratory function using nasal nitric oxide (nNO) levels and nasal ciliary motion observed in video microscopy. Data collected included demographics, surgical details, postoperative complications, length of stay, ICU hours, salvage procedures, intubation duration, and mortality.
UNASSIGNED: The CD and no-CD cohorts exhibited notable similarities in risk adjustment in Congenital Heart Surgery-1 (RACHS-1) risk categories, age at the time of surgery, and the duration of follow-up evaluations. We observed a trend toward an increased length of post-operative stay in the CD group (15.0 vs. 14.0; P = 0.0017). CHD-HTX patients with CD showed significantly higher rates of respiratory complications (70% vs. 44.4%; P = 0.008). There were no notable variances observed in postoperative hospitalization duration, mechanical ventilation period, or surgical mortality.
UNASSIGNED: Our findings suggest that CHD-HTX patients with CD may face an elevated risk of respiratory complications. These results offer guidance for perioperative management and serve as a reference for further pathological studies.
摘要：
■先天性心脏病-异位症（CHD-HTX）患者的心脏手术通常会导致术后气道并发症增加。呼吸纤毛功能异常,类似于原发性纤毛运动障碍，已被观察到。我们通过回顾性回顾CHD-HTX患者的纤毛功能障碍（CD）来扩大样本量，以验证术后呼吸系统并发症的风险增加。
■我们对69例接受心脏手术的CHD-HTX患者进行了回顾性研究，使用视频显微镜中观察到的鼻一氧化氮（nNO）水平和鼻纤毛运动评估异常呼吸功能。收集的数据包括人口统计，手术细节,术后并发症,逗留时间,ICU小时数,打捞程序,插管持续时间,和死亡率。
■CD和无CD队列在先天性心脏手术-1（RACHS-1）风险类别的风险调整方面表现出明显的相似性，手术时的年龄，以及后续评估的持续时间。我们观察到CD组术后住院时间有增加的趋势(15.0vs.14.0；P=0.0017）。患有CD的CHD-HTX患者的呼吸系统并发症发生率显着升高（70％vs.44.4%；P=0.008）。术后住院时间无显著差异，机械通气期,或手术死亡率。
■我们的研究结果表明，患有CD的CHD-HTX患者可能面临呼吸道并发症的风险增加。这些结果为围手术期管理提供了指导，并为进一步的病理研究提供了参考。
■我们对69例接受心脏手术的CHD-HTX患者进行了回顾性研究，使用视频显微镜中观察到的鼻一氧化氮（nNO）水平和鼻纤毛运动评估异常呼吸功能。收集的数据包括人口统计，手术细节,术后并发症,逗留时间,ICU小时数,打捞程序,插管持续时间,和死亡率。
■CD和无CD队列在先天性心脏手术-1（RACHS-1）风险类别的风险调整方面表现出明显的相似性，手术时的年龄，以及后续评估的持续时间。我们观察到CD组术后住院时间有增加的趋势(15.0vs.14.0；P=0.0017）。患有CD的CHD-HTX患者的呼吸系统并发症发生率显着升高（70％vs.44.4%；P=0.008）。术后住院时间无显著差异，机械通气期,或手术死亡率。
■我们的研究结果表明，患有CD的CHD-HTX患者可能面临呼吸道并发症的风险增加。这些结果为围手术期管理提供了指导，并为进一步的病理研究提供了参考。
