PDF(Pubmed)
Abstract：
Recently, the use of assisted reproductive technology (ART) has rapidly increased. As a result, an increasing number of people are concerned about the safety of offspring produced through ART. Moreover, emerging evidence suggests an increased risk of cardiovascular disease (CVD) in offspring conceived using ART. In this review, we discuss the epigenetic mechanisms involved in altered DNA methylation, histone modification, and microRNA expression, as well as imprinting disorders. We also summarize studies on cardiovascular changes and other risk factors for cardiovascular disease, such as adverse intrauterine environments, perinatal complications, and altered metabolism following assisted reproductive technology (ART). Finally, we emphasize the epigenetic mechanisms underlying the increased risk of CVD in offspring conceived through ART, which could contribute to the early diagnosis and prevention of CVD in the ART population.
摘要：
最近,辅助生殖技术（ART）的使用迅速增加。因此,越来越多的人担心通过ART产生的后代的安全性。此外，新出现的证据表明，使用ART受孕的后代患心血管疾病（CVD）的风险增加。在这次审查中,我们讨论了DNA甲基化改变的表观遗传机制，组蛋白修饰，和microRNA表达，以及印记障碍。我们还总结了心血管变化和其他心血管疾病危险因素的研究，如不良的宫内环境，围产期并发症，辅助生殖技术（ART）后代谢改变。最后,我们强调了通过ART受孕的后代心血管疾病风险增加的表观遗传机制，这可能有助于ART人群中CVD的早期诊断和预防。
