Abstract：
BACKGROUND: Wound healing poses a challenging therapeutic scenario, requiring diverse clinical approaches.
OBJECTIVE: This study aims to assess the wound-healing potential of Salix aegyptiaca\'s flower ointment compared to phenytoin, considering the active constituents of S. aegyptiaca and its traditional usage.
METHODS: Initially, the active components of S. aegyptiaca were isolated and identified through the GC-MS technique. Subsequently, for the experimental intervention, thirty-five rats were divided into five distinct groups: control (C), phenytoin (F), and three S. aegyptiaca ointment groups at different concentrations (5 % - S5, 25 % - S25, and 50 % - S50). Anesthesia was administered, and wounds were induced on the animals\' necks following a standard procedure. These wounds were then treated for a duration of 21 days. Wound healing progress was quantified, and histopathological assessments were conducted using hematoxylin and eosin staining and Mason\'s trichrome staining.
RESULTS: The main active compounds of S. aegyptiaca, namely n-hexadecanoic acid and oleic acid, were identified via GC-MS analysis. Although the initial group weights did not show a significant difference (P = 0.271), a significant variation was observed in the final weights (P = 0.003). The S50 group exhibited a lower wound healing rate than the S25 group on the 7th and 14th days but surpassed it on the 21st day (C < F < S5≈S25CONCLUSIONS: The findings highlight the superior wound-healing efficacy of 50 % S. aegyptiaca ointment over phenytoin ointment.
OBJECTIVE: This study aims to assess the wound-healing potential of Salix aegyptiaca\'s flower ointment compared to phenytoin, considering the active constituents of S. aegyptiaca and its traditional usage.
METHODS: Initially, the active components of S. aegyptiaca were isolated and identified through the GC-MS technique. Subsequently, for the experimental intervention, thirty-five rats were divided into five distinct groups: control (C), phenytoin (F), and three S. aegyptiaca ointment groups at different concentrations (5 % - S5, 25 % - S25, and 50 % - S50). Anesthesia was administered, and wounds were induced on the animals\' necks following a standard procedure. These wounds were then treated for a duration of 21 days. Wound healing progress was quantified, and histopathological assessments were conducted using hematoxylin and eosin staining and Mason\'s trichrome staining.
RESULTS: The main active compounds of S. aegyptiaca, namely n-hexadecanoic acid and oleic acid, were identified via GC-MS analysis. Although the initial group weights did not show a significant difference (P = 0.271), a significant variation was observed in the final weights (P = 0.003). The S50 group exhibited a lower wound healing rate than the S25 group on the 7th and 14th days but surpassed it on the 21st day (C < F < S5≈S25
摘要：
背景：伤口愈合构成了一个具有挑战性的治疗方案，需要不同的临床方法。
目的：本研究旨在评估与苯妥英钠相比，柳柳花软膏的伤口愈合潜力，考虑到埃及伊蚊的活性成分及其传统用法。
方法：最初，通过GC-MS技术分离并鉴定了埃及毛藻的活性成分。随后，对于实验性干预，将35只大鼠分为五个不同的组：对照组（C），苯妥英（F），和三个不同浓度的埃及酵母软膏组（5％-S5，25％-S25和50％-S50）。进行了麻醉，并按照标准程序在动物脖子上诱导伤口。然后将这些伤口处理21天的持续时间。量化伤口愈合进展，和组织病理学评估使用苏木精和伊红染色和梅森三色染色进行。
结果：埃及伊蚊的主要活性化合物，即正十六烷酸和油酸，通过GC-MS分析鉴定。尽管初始组的体重没有显着差异（P=0.271），在最终体重中观察到显著差异(P=0.003).S50组在第7天和第14天的伤口愈合率低于S25组，但在第21天超过了伤口愈合率（C结论：研究结果强调了50％埃及链球菌软膏优于苯妥英软膏的伤口愈合功效。
目的：本研究旨在评估与苯妥英钠相比，柳柳花软膏的伤口愈合潜力，考虑到埃及伊蚊的活性成分及其传统用法。
方法：最初，通过GC-MS技术分离并鉴定了埃及毛藻的活性成分。随后，对于实验性干预，将35只大鼠分为五个不同的组：对照组（C），苯妥英（F），和三个不同浓度的埃及酵母软膏组（5％-S5，25％-S25和50％-S50）。进行了麻醉，并按照标准程序在动物脖子上诱导伤口。然后将这些伤口处理21天的持续时间。量化伤口愈合进展，和组织病理学评估使用苏木精和伊红染色和梅森三色染色进行。
结果：埃及伊蚊的主要活性化合物，即正十六烷酸和油酸，通过GC-MS分析鉴定。尽管初始组的体重没有显着差异（P=0.271），在最终体重中观察到显著差异(P=0.003).S50组在第7天和第14天的伤口愈合率低于S25组，但在第21天超过了伤口愈合率（C
