Abstract：
An in vivo model is necessary for toxicology. This review analyzed the uses of zebrafish (Danio rerio) in toxicology based on bibliometrics. Totally 56,816 publications about zebrafish from 2002 to 2023 were found in Web of Science Core Collection, with Toxicology as the top 6 among all disciplines. Accordingly, the bibliometric map reveals that \"toxicity\" has become a hot keyword. It further reveals that the most common exposure types include acute, chronic, and combined exposure. The toxicological effects include behavioral, intestinal, cardiovascular, hepatic, endocrine toxicity, neurotoxicity, immunotoxicity, genotoxicity, and reproductive and transgenerational toxicity. The mechanisms include oxidative stress, inflammation, autophagy, and dysbiosis of gut microbiota. The toxicants commonly evaluated by using zebrafish model include nanomaterials, arsenic, metals, bisphenol, and dioxin. Overall, zebrafish provide a unique and well-accepted model to investigate the toxicological effects and mechanisms. We also discussed the possible ways to address some of the limitations of zebrafish model, such as the combination of human organoids to avoid species differences.
摘要：
体内模型对于毒理学是必要的。本文基于文献计量学分析了斑马鱼（Daniorerio）在毒理学中的应用。从2002年到2023年，共有56,816种关于斑马鱼的出版物被发现在WebofScienceCoreCollection中。毒理学是所有学科中的前6名。因此，文献计量图显示，“毒性”已成为热门关键词。它进一步揭示了最常见的暴露类型包括急性，慢性，和组合曝光。毒理学影响包括行为，肠,心血管,肝，内分泌毒性，神经毒性，免疫毒性,遗传毒性，生殖和跨代毒性。其机制包括氧化应激，炎症,自噬,和肠道微生物群的生态失调。通常使用斑马鱼模型评估的毒物包括纳米材料，砷,金属，双酚,还有二恶英.总的来说,斑马鱼提供了一种独特且广为接受的模型来研究其毒理学作用和机制。我们还讨论了解决斑马鱼模型的一些局限性的可能方法，例如人类类器官的组合，以避免物种差异。
