PDF(Pubmed)
Abstract：
BACKGROUND: Chronic liver disease has been reported to be associated with peripheral neuropathy. However, which sensory fibers are affected remains unknown. The objective of this study was to examine the function of sensory nerve fibers in patients with cirrhosis using the current perception threshold (CPT) test, as well as the correlation between blood biochemical indicators related to cirrhosis and CPT values.
METHODS: We recruited 44 patients with liver cirrhosis and 37 healthy controls of the same age and gender. The Neurometer® system for the CPT test was used to stimulate the median nerve on the right index finger, as well as the deep and superficial peroneal nerves on the right hallux, using three distinct parameters (2000 Hz, 250 Hz, and 5 Hz). Comparative analysis was performed on the CPT values of the sensory nerves. Additionally, the correlation between CPT values and biochemical blood indicators in the study participants was analyzed.
RESULTS: Under 2000 Hz electrical stimulation, there was a significant difference between the cirrhosis and healthy control groups in the median nerve as well as the deep and superficial peroneal nerves (p < 0.05). In addition, the median nerve CPT value of the cirrhosis group was significantly higher than that of the control group at an electrical stimulation frequency of 250 Hz (p = 0.005). There was no correlation between CPT values and blood biochemical indicators.
CONCLUSIONS: According to the results, the sensory peripheral neuropathy in liver cirrhosis is mainly manifested as Aβ fiber neuropathy.
METHODS: We recruited 44 patients with liver cirrhosis and 37 healthy controls of the same age and gender. The Neurometer® system for the CPT test was used to stimulate the median nerve on the right index finger, as well as the deep and superficial peroneal nerves on the right hallux, using three distinct parameters (2000 Hz, 250 Hz, and 5 Hz). Comparative analysis was performed on the CPT values of the sensory nerves. Additionally, the correlation between CPT values and biochemical blood indicators in the study participants was analyzed.
RESULTS: Under 2000 Hz electrical stimulation, there was a significant difference between the cirrhosis and healthy control groups in the median nerve as well as the deep and superficial peroneal nerves (p < 0.05). In addition, the median nerve CPT value of the cirrhosis group was significantly higher than that of the control group at an electrical stimulation frequency of 250 Hz (p = 0.005). There was no correlation between CPT values and blood biochemical indicators.
CONCLUSIONS: According to the results, the sensory peripheral neuropathy in liver cirrhosis is mainly manifested as Aβ fiber neuropathy.
摘要：
背景：据报道，慢性肝病与周围神经病变有关。然而,哪些感觉纤维受到影响仍然未知。本研究的目的是使用当前感知阈值（CPT）测试检查肝硬化患者的感觉神经纤维功能，以及与肝硬化相关的血液生化指标与CPT值的相关性。
方法：我们招募了44例肝硬化患者和37例相同年龄和性别的健康对照。用于CPT测试的Neurometer®系统用于刺激右手食指的正中神经，以及右拇指上的腓骨深和浅神经，使用三个不同的参数(2000赫兹，250Hz,和5Hz）。对感觉神经的CPT值进行比较分析。此外,分析研究参与者的CPT值与血液生化指标之间的相关性.
结果：在2000Hz电刺激下，肝硬化组与健康对照组的正中神经、腓深神经和腓浅神经差异有统计学意义(p<0.05)。此外,在250Hz的电刺激频率下,肝硬化组的正中神经CPT值显著高于对照组(p=0.005).CPT值与血液生化指标无相关性。
结论：根据结果，肝硬化的感觉周围神经病变主要表现为Aβ纤维神经病变。
方法：我们招募了44例肝硬化患者和37例相同年龄和性别的健康对照。用于CPT测试的Neurometer®系统用于刺激右手食指的正中神经，以及右拇指上的腓骨深和浅神经，使用三个不同的参数(2000赫兹，250Hz,和5Hz）。对感觉神经的CPT值进行比较分析。此外,分析研究参与者的CPT值与血液生化指标之间的相关性.
结果：在2000Hz电刺激下，肝硬化组与健康对照组的正中神经、腓深神经和腓浅神经差异有统计学意义(p<0.05)。此外,在250Hz的电刺激频率下,肝硬化组的正中神经CPT值显著高于对照组(p=0.005).CPT值与血液生化指标无相关性。
结论：根据结果，肝硬化的感觉周围神经病变主要表现为Aβ纤维神经病变。
