OBJECTIVE: We aimed to compare the efficacy of topical latanoprost 0.005% (Ioprost®, Orchidia, Egypt) combined with either add-on fractional CO2 laser or fractional CO2 -PRP versus topical latanoprost monotherapy in the treatment of localized stable vitiligo.
METHODS: The study included 60 patients randomly assigned into three equal groups. Group A patients received topical latanoprost drops only. Group B patients received topical latanoprost drops and fractional CO2 laser sessions at 2-week interval for 3 months. Group C patients received topical latanoprost drops and fractional CO2 laser sessions combined with PRP at a 2-week interval for 3 months. The mean improvement score by the physician was calculated 4 months after the start of the study. Punch skin biopsies were obtained before treatment and 4 months from the beginning of the study and stained with H&E and HMB-45 antibody for evaluation of pigmentation.
RESULTS: Significant clinical improvement of vitiligo lesions with significant increase of re-pigmentation were reported in the three treated groups. Latanoprost in combination with fractional CO2 and PRP was associated with more significant therapeutic outcomes than either combined latanoprost and fractional CO2 or latanoprost alone.
CONCLUSIONS: Fractional CO2 laser-PRP enhances the therapeutic efficacy of latanoprost 0.005% in the treatment of localized stable vitiligo.
目的:我们旨在比较0.005%外用拉坦前列素的疗效(Ioprost®,Orchidia,埃及)联合附加分数CO2激光或分数CO2-PRP与局部拉坦前列素单一疗法治疗局部稳定型白癜风。
方法:该研究包括60名患者,随机分为3组。A组患者仅接受局部拉坦前列素滴剂。B组患者以2周的间隔接受局部拉坦前列素滴剂和部分CO2激光治疗,为期3个月。C组患者以2周的间隔接受局部拉坦前列素滴剂和分数CO2激光治疗联合PRP,为期3个月。在研究开始后4个月计算医师的平均改善评分。在治疗前和从研究开始4个月获得穿刺皮肤活检,并用H&E和HMB-45抗体染色以评估色素沉着。
结果:在三个治疗组中报告了白癜风病变的显着临床改善和色素沉着的显着增加。与单独使用拉坦前列素和部分CO2或单独使用拉坦前列素相比,拉坦前列素与部分CO2和PRP联合使用具有更重要的治疗效果。
结论:分数CO2激光-PRP可提高拉坦前列素0.005%治疗局部稳定期白癜风的疗效。