PDF(Pubmed)
Abstract：
UNASSIGNED: Although both anemia and schizophrenia (SCZ) can cause cognitive decline, it is unclear whether anemia worsens cognitive decline in patients with SCZ. The primary objective of this study was to investigate the prevalence of anemia and the relationship between anemia, SCZ symptom severity, and cognitive function in patients with SCZ.
UNASSIGNED: We obtained demographic and clinical data from 1690 inpatients with SCZ. All psychiatric symptoms and cognitive functioning were assessed by the Positive and Negative Syndrome Scale (PANSS), the Mini-Mental State Examination (MMSE), and the Repeated Battery for the Assessment of Neuropsychological Status (RBANS). Hemoglobin (HGB) values as well as red blood cell (RBC) counts were collected by routine blood tests.
UNASSIGNED: The proportion of anemia in patients with SCZ was 26.36 % (383/1453). Compared to SCZ patients without anemia, SCZ patients with anemia were older, had a lower bodyweight, a smaller waist circumference and lower apolipoprotein B levels, but longer QT intervals. Further logistic regression analysis revealed that anemia was associated with age, gender, and weight. In addition, there was no difference in cognitive function between SCZ patients with and without anemia.
UNASSIGNED: Our findings suggest a high proportion of anemia in patients with chronic SCZ in the Han Chinese population. Several demographic and clinical variables are associated with anemia in SCZ patients.
UNASSIGNED: We obtained demographic and clinical data from 1690 inpatients with SCZ. All psychiatric symptoms and cognitive functioning were assessed by the Positive and Negative Syndrome Scale (PANSS), the Mini-Mental State Examination (MMSE), and the Repeated Battery for the Assessment of Neuropsychological Status (RBANS). Hemoglobin (HGB) values as well as red blood cell (RBC) counts were collected by routine blood tests.
UNASSIGNED: The proportion of anemia in patients with SCZ was 26.36 % (383/1453). Compared to SCZ patients without anemia, SCZ patients with anemia were older, had a lower bodyweight, a smaller waist circumference and lower apolipoprotein B levels, but longer QT intervals. Further logistic regression analysis revealed that anemia was associated with age, gender, and weight. In addition, there was no difference in cognitive function between SCZ patients with and without anemia.
UNASSIGNED: Our findings suggest a high proportion of anemia in patients with chronic SCZ in the Han Chinese population. Several demographic and clinical variables are associated with anemia in SCZ patients.
摘要：
■尽管贫血和精神分裂症（SCZ）都会导致认知功能下降，目前尚不清楚贫血是否会加重SCZ患者的认知功能减退.这项研究的主要目的是调查贫血的患病率和贫血之间的关系。SCZ症状严重程度，SCZ患者的认知功能。
■我们获得了1690例SCZ住院患者的人口统计学和临床数据。所有精神症状和认知功能均采用阳性和阴性综合征量表（PANSS）进行评估，迷你精神状态检查(MMSE)，以及评估神经心理状态的重复电池（RBANS）。通过常规血液测试收集血红蛋白（HGB）值以及红细胞（RBC）计数。
■SCZ患者贫血的比例为26.36%(383/1453)。与无贫血的SCZ患者相比，SCZ贫血患者年龄较大，体重较低，较小的腰围和较低的载脂蛋白B水平，但QT间隔较长。进一步logistic回归分析显示贫血与年龄有关,性别,和重量。此外,有和没有贫血的SCZ患者的认知功能没有差异。
■我们的研究结果表明，在中国汉族人群中，慢性SCZ患者的贫血比例很高。SCZ患者中的一些人口统计学和临床变量与贫血相关。
■我们获得了1690例SCZ住院患者的人口统计学和临床数据。所有精神症状和认知功能均采用阳性和阴性综合征量表（PANSS）进行评估，迷你精神状态检查(MMSE)，以及评估神经心理状态的重复电池（RBANS）。通过常规血液测试收集血红蛋白（HGB）值以及红细胞（RBC）计数。
■SCZ患者贫血的比例为26.36%(383/1453)。与无贫血的SCZ患者相比，SCZ贫血患者年龄较大，体重较低，较小的腰围和较低的载脂蛋白B水平，但QT间隔较长。进一步logistic回归分析显示贫血与年龄有关,性别,和重量。此外,有和没有贫血的SCZ患者的认知功能没有差异。
■我们的研究结果表明，在中国汉族人群中，慢性SCZ患者的贫血比例很高。SCZ患者中的一些人口统计学和临床变量与贫血相关。
