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Abstract：
The increased utilization of titanium dioxide (TiO2) nanoparticles (TNPs) in various industrial and consumer products has raised concerns regarding its harmful effect due to its accumulation within the different systems of the human body. Here, we focused on the influence of TNPs on the growth and aggregation of two crucial crystalline substances, calcium phosphate (CaP) and monosodium urate (MSU), particularly its implications in gout disease. In this study, we adopted microscopic techniques and generated kinetic models to examine the interactions between TNPs, CaP and MSU, and crystallization, under controlled laboratory conditions. Our findings reveal that TNPs not only facilitate the growth of these crystals but also promote their co-aggregations. Crystal dissolution kinetics also exhibit that an increase in TNPs concentration corresponds to a reduction in the dissolution rate of CaP and MSU crystals in presence of the dissoluting agent hydroxycitrate (Hcit). These observations suggest that TNPs can stabilize CaP+MSU mixed crystals, which underscores the significance of TNPs\' exposure in the pathogenesis of gout disease.
摘要：
二氧化钛（TiO2）纳米颗粒（TNP）在各种工业和消费品中的利用增加，引起了人们对其有害影响的关注，因为它在人体不同系统中的积累。这里,我们专注于TNP对两种关键晶体物质生长和聚集的影响，磷酸钙（CaP）和尿酸单钠（MSU），尤其是它对痛风疾病的影响。在这项研究中,我们采用微观技术和生成的动力学模型来检查TNP之间的相互作用，CaP和MSU,和结晶，在受控的实验室条件下。我们的发现表明，TNP不仅促进了这些晶体的生长，而且促进了它们的共聚集。晶体溶解动力学还显示,在溶解剂羟基柠檬酸盐(Hcit)的存在下,TNP浓度的增加对应于CaP和MSU晶体的溶解速率的降低。这些观察结果表明，TNP可以稳定CaP+MSU混合晶体，这强调了TNP暴露在痛风疾病发病机制中的重要性。
