PDF(Pubmed)
Abstract：
This study investigated the efficacy of topical cannabidiol (CBD) ointment in reducing localized inflammation, minimizing performance detriments, and attenuating soreness associated with delayed onset muscle soreness (DOMS). In a double blind randomized control trial, upper-arm circumferences, maximal voluntary isometric contractions (MVICs) for elbow flexion at 90° and 30° for college-aged participants (n = 21, age 20.8 ± 1.9 years) were assessed at baseline. Participants then performed a DOMS-inducing protocol for the biceps brachii. Topical CBD ointment and placebo (P) ointment were randomly assigned and applied 30 minutes, 24, 48 and 72 hours post the DOMS protocol. The baseline parameters and a visual analog scale (VAS) to assess perceived soreness were assessed 24, 48 and 72 hours post DOMS protocol. A 4x2 repeated measures factorial ANOVA (P < 0.05) analyzed both within and between subject differences. No changes were statistically significant on any days between conditions: Upper-arm circumferences in the CBD arm (7.1 ± 5.8 cm) and in the P arm (7.3 ± 5.8 cm). MVICs were reduced at both the 90° and 30° positions (-5.9 ± 9.0 Nm (90°)); (-4.8 ± 6.5 Nm (30°)) and the P arm (-5.0 ± 10.0 Nm (90°)); (-4.6 ± 5.3 Nm (30°)). Soreness increased in both the CBD arm (6.1 ± 2.1) and the P arm (5.5 ± 2.6) over time. Topical CBD therefore did not alter any parameters vs the P treatment, thus the use of topical CBD does not attenuate the effects of DOMS.
摘要：
这项研究调查了局部大麻二酚（CBD）软膏在减少局部炎症中的功效，将性能损害降至最低，并减轻与延迟性肌肉酸痛（DOMS）相关的酸痛。在一项双盲随机对照试验中，上臂圆周,在基线时评估了大学年龄参与者(n=21,年龄20.8±1.9岁)在90°和30°时肘部屈曲的最大自愿性等距收缩(MVIC).然后，参与者对肱二头肌进行了DOMS诱导方案。局部CBD软膏和安慰剂（P）软膏被随机分配并应用30分钟，DOMS协议后24、48和72小时。在DOMS方案后24、48和72小时评估基线参数和视觉模拟量表(VAS)以评估感知的疼痛。4x2重复测量阶乘方差分析(P<0.05)分析受试者内和受试者之间的差异。在两种情况之间的任何一天，均无统计学意义：CBD臂（7.1±5.8cm）和P臂（7.3±5.8cm）的上臂周长。在90°和30°位置（-5.9±9.0Nm（90°）；（-4.8±6.5Nm（30°））和P臂（-5.0±10.0Nm（90°））；（-4.6±5.3Nm（30°））均降低了MVIC。随着时间的流逝，CBD臂（6.1±2.1）和P臂（5.5±2.6）的酸痛均增加。因此，与P治疗相比，局部CBD没有改变任何参数，因此，使用局部CBD不会减弱DOMS的影响。
