PDF(Pubmed)
Abstract：
OBJECTIVE: Bilateral femoral distraction osteogenesis in patients with achondroplasia is insufficiently reported. We aimed to perform the first study that exclusively analyzed simultaneous bilateral femoral distraction osteogenesis with motorized intramedullary lengthening nails via an antegrade approach in patients with achondroplasia focused on reliability, accuracy, precision, and the evolving complications.
METHODS: In this retrospective singlecenter study we analyzed patients with achondroplasia who underwent simultaneous bilateral femoral lengthening with antegrade intramedullary lengthening nails between October 2014 and April 2019. 15 patients (30 femoral segments) of median age 14 years (interquartile range [IQR] 12-15) were available for analysis. The median follow-up was 29 months (IQR 27-37) after nail implantation.
RESULTS: The median distraction length per segment was 49 mm (IQR 47-51) with a median distraction index of 1.0 mm/day (IQR 0.9-1.0), and a median consolidation index of 20 days/cm (IQR 17-23). Reliability of the lengthening nails was 97% and their calculated accuracy and precision were 96% and 95%, respectively. The most common complication was temporary restriction of knee range of motion during distraction in 10 of 30 of the lengthened segments. 1 patient was treated with 2 unplanned additional surgeries due to premature consolidation.
CONCLUSIONS: The method is reliable and accurate with few complications.
METHODS: In this retrospective singlecenter study we analyzed patients with achondroplasia who underwent simultaneous bilateral femoral lengthening with antegrade intramedullary lengthening nails between October 2014 and April 2019. 15 patients (30 femoral segments) of median age 14 years (interquartile range [IQR] 12-15) were available for analysis. The median follow-up was 29 months (IQR 27-37) after nail implantation.
RESULTS: The median distraction length per segment was 49 mm (IQR 47-51) with a median distraction index of 1.0 mm/day (IQR 0.9-1.0), and a median consolidation index of 20 days/cm (IQR 17-23). Reliability of the lengthening nails was 97% and their calculated accuracy and precision were 96% and 95%, respectively. The most common complication was temporary restriction of knee range of motion during distraction in 10 of 30 of the lengthened segments. 1 patient was treated with 2 unplanned additional surgeries due to premature consolidation.
CONCLUSIONS: The method is reliable and accurate with few complications.
摘要：
目的：软骨发育不全患者双侧股骨牵张成骨的报道不充分。我们旨在进行第一项研究，该研究专门分析了通过顺行方法对软骨发育不全患者进行的同时双侧股骨牵张与电动髓内延长钉的同时成骨作用，重点是可靠性。准确度,精度,和不断发展的并发症。
方法：在这项回顾性单中心研究中，我们分析了在2014年10月至2019年4月期间同时进行双侧股骨延长和顺行髓内延长钉的软骨发育不全患者。15名中位年龄14岁（四分位距[IQR]12-15）的患者（30个股骨段）可用于分析。中位随访时间为钉植入后29个月（IQR27-37）。
结果：每段的中位牵张长度为49mm（IQR47-51），中位牵张指数为1.0mm/天（IQR0.9-1.0），合并指数中位数为20天/厘米（IQR17-23）。延长钉的可靠性为97％，其计算精度和精度分别为96％和95％，分别。最常见的并发症是在30个加长段中的10个中，在牵引过程中暂时限制了膝盖的运动范围。1例患者因过早巩固而接受2例非计划的额外手术治疗。
结论：该方法可靠、准确，并发症少。
方法：在这项回顾性单中心研究中，我们分析了在2014年10月至2019年4月期间同时进行双侧股骨延长和顺行髓内延长钉的软骨发育不全患者。15名中位年龄14岁（四分位距[IQR]12-15）的患者（30个股骨段）可用于分析。中位随访时间为钉植入后29个月（IQR27-37）。
结果：每段的中位牵张长度为49mm（IQR47-51），中位牵张指数为1.0mm/天（IQR0.9-1.0），合并指数中位数为20天/厘米（IQR17-23）。延长钉的可靠性为97％，其计算精度和精度分别为96％和95％，分别。最常见的并发症是在30个加长段中的10个中，在牵引过程中暂时限制了膝盖的运动范围。1例患者因过早巩固而接受2例非计划的额外手术治疗。
结论：该方法可靠、准确，并发症少。
