Abstract：
Marine-based dietary oils (MDOs), which are naturally obtained from different sources, have been scientifically recommended as potent functional bioactives owing to their therapeutic biological activities; however, they have exhibited plenty of health benefits. Though they are very sensitive to light, temperature, moisture, and oxygen, as well as being chemically unstable and merely oxidized, this may limit their utilization in food and pharmaceutical products. Miro- and nanoencapsulation techniques are considered to be the most promising tactics for enhancing the original characteristics, physiochemical properties, and therapeutic effects of entrapped MDOs. This review focuses on the biomacromolecule-stabilized micro/nanocarriers encompassing a wide range of MDOs. The novel-equipped polysaccharides and protein-based micro/nanocarriers cover microemulsions, microcapsules, nanoemulsions, and nanoliposomes, which have been proven to be encouraging candidates for the entrapment of diverse kinds of MDOs. In addition, the current state-of-the-art loading of various MDOs through polysaccharide and protein-based micro/nanocarriers has been comprehensively discussed and tabulated in detail. Biomacromolecule-stabilized nanocarriers, particularly nanoemulsions and nanoliposomes, are addressed as propitious nanocargos for protection of MDOs in response to thought-provoking features as well as delivering the successful, meticulous release to the desired sites. Gastrointestinal fate (GF) of biopolymeric micro/nanocarriers is fundamentally based on their centrifugation, dimension, interfacial, and physical properties. The external surface of epithelial cells in the lumen is the main site where the absorption of lipid-based nanoparticles takes place. MDO-loaded micro- and nanocarriers with biological origins or structural modifications have shown some novel applications that could be used as future therapies for cardiovascular disorders, thanks to today\'s cutting-edge medical technology. In the future, further investigations are highly needed to open new horizons regarding the application of polysaccharide and protein-based micro/nanocarriers in food and beverage products with the possibility of commercialization in the near future for industrial use.
摘要：
海洋膳食油（MDO），它们自然是从不同来源获得的，由于其治疗性生物活性，已被科学推荐为有效的功能性生物活性物质；然而，他们表现出许多健康益处。虽然它们对光非常敏感，温度,水分,和氧气,除了化学上不稳定和仅仅被氧化，这可能会限制它们在食品和药品中的利用。Miro和纳米封装技术被认为是增强原始特性的最有前途的策略，理化性质，以及截留的MDO的治疗效果。这篇综述的重点是涵盖广泛的MDO的生物大分子稳定的微/纳米载体。新装备的多糖和基于蛋白质的微/纳米载体覆盖微乳液，微胶囊,纳米乳液，和纳米脂质体，这已被证明是鼓励捕获各种MDO的候选人。此外,通过多糖和基于蛋白质的微/纳米载体的各种MDO的当前最先进的负载已经被全面讨论和详细列表。生物大分子稳定的纳米载体，特别是纳米乳液和纳米脂质体，被认为是保护MDO的有利的纳米陶器，以响应发人深省的特征，并提供成功的，细致地释放到所需的网站。生物聚合物微/纳米载体的胃肠道命运（GF）从根本上是基于它们的离心，维度,界面,和物理性质。内腔中上皮细胞的外表面是发生基于脂质的纳米颗粒的吸收的主要部位。具有生物起源或结构修饰的MDO负载的微载体和纳米载体已显示出一些新颖的应用，可用作心血管疾病的未来疗法。多亏了今天的尖端医疗技术。在未来,进一步的研究是非常需要打开新的视野有关的应用多糖和蛋白质基的微/纳米载体在食品和饮料产品，有可能在不久的将来商业化用于工业用途。
