Abstract：
OBJECTIVE: The aim is to investigate the clinical characteristics of systemic lupus erythematosus with intracranial hypertension.
METHODS: The clinical characteristics of one case of systemic lupus erythematosus with chronic persistent intracranial hypertension were analyzed, and related literature was reviewed by searching Medline and Wanfang databases.
RESULTS: Intracranial hypertension in SLE patients may occur at the onset or during the course of the disease. Our patient was diagnosed with IH 3 years after the onset of SLE. Headache and papilledema were the most common symptoms of intracranial hypertension, followed by nausea or vomiting, vision changes, and cerebral palsy. Our patient had a headache and cranial hypertension that lasted for years, but no papilledema was found. Corticosteroid is currently the mainstay of the treatment of IIH in patients with SLE, and immunosuppressive agents, acetazolamide, intravenous mannitol and furosemide are also used. However, our patient did not respond to these treatments and presents the characteristics of chronic persistent intracranial hypertension.
CONCLUSIONS: Systemic lupus erythematosus with intracranial hypertension is a rare manifestation of SLE, which is not completely parallel to SLE activity. Headache and papilledema were the most common presenting symptoms. Different from previous reported cases, our patient had poor response to treatments, showing chronic and persistent characteristics.
METHODS: The clinical characteristics of one case of systemic lupus erythematosus with chronic persistent intracranial hypertension were analyzed, and related literature was reviewed by searching Medline and Wanfang databases.
RESULTS: Intracranial hypertension in SLE patients may occur at the onset or during the course of the disease. Our patient was diagnosed with IH 3 years after the onset of SLE. Headache and papilledema were the most common symptoms of intracranial hypertension, followed by nausea or vomiting, vision changes, and cerebral palsy. Our patient had a headache and cranial hypertension that lasted for years, but no papilledema was found. Corticosteroid is currently the mainstay of the treatment of IIH in patients with SLE, and immunosuppressive agents, acetazolamide, intravenous mannitol and furosemide are also used. However, our patient did not respond to these treatments and presents the characteristics of chronic persistent intracranial hypertension.
CONCLUSIONS: Systemic lupus erythematosus with intracranial hypertension is a rare manifestation of SLE, which is not completely parallel to SLE activity. Headache and papilledema were the most common presenting symptoms. Different from previous reported cases, our patient had poor response to treatments, showing chronic and persistent characteristics.
摘要：
目的：探讨系统性红斑狼疮合并颅内高压的临床特点。
方法：分析1例系统性红斑狼疮合并慢性持续性颅内高压的临床特点。并通过搜索Medline和Wanfang数据库对相关文献进行了综述。
结果：SLE患者的颅内高压可能发生在发病时或病程中。我们的患者在SLE发作3年后被诊断为IH。头痛和乳头水肿是颅内高压最常见的症状，然后出现恶心或呕吐,视力变化,和脑瘫.我们的病人头痛和颅内高血压持续多年，但没有发现乳头水肿.皮质类固醇是目前治疗SLE患者IIH的主要药物,和免疫抑制剂，乙酰唑胺,还使用静脉注射甘露醇和呋塞米。然而,我们的患者对这些治疗没有反应,并且表现出慢性持续性颅内高压的特征.
结论：系统性红斑狼疮合并颅内高压是SLE的罕见表现，这并不完全平行于SLE活动。头痛和乳头水肿是最常见的症状。与以往报道的病例不同,我们的病人对治疗反应不佳，表现出慢性和持续性的特征。
方法：分析1例系统性红斑狼疮合并慢性持续性颅内高压的临床特点。并通过搜索Medline和Wanfang数据库对相关文献进行了综述。
结果：SLE患者的颅内高压可能发生在发病时或病程中。我们的患者在SLE发作3年后被诊断为IH。头痛和乳头水肿是颅内高压最常见的症状，然后出现恶心或呕吐,视力变化,和脑瘫.我们的病人头痛和颅内高血压持续多年，但没有发现乳头水肿.皮质类固醇是目前治疗SLE患者IIH的主要药物,和免疫抑制剂，乙酰唑胺,还使用静脉注射甘露醇和呋塞米。然而,我们的患者对这些治疗没有反应,并且表现出慢性持续性颅内高压的特征.
结论：系统性红斑狼疮合并颅内高压是SLE的罕见表现，这并不完全平行于SLE活动。头痛和乳头水肿是最常见的症状。与以往报道的病例不同,我们的病人对治疗反应不佳，表现出慢性和持续性的特征。
