PDF(Pubmed)
Abstract：
Vernal keratoconjunctivitis (VKC) is a bilateral ocular inflammatory disease with a conjunctival and corneal involvement and typical onset during childhood. Eosinophilic esophagitis (EoE) is a chronic disease characterized by eosinophilic inflammation of the mucosa (≥15 eosinophils/HPF) and symptoms of esophageal dysfunction. EoE and VKC are both immune-mediated diseases sharing a similar pathogenetic mechanism and a high association with other allergic diseases. Nevertheless, no data are currently available about their clinical association. We present 4 cases of concomitant diagnosis of vernal keratoconjunctivitis and eosinophil esophagitis suggesting that these conditions may coexist in the same patient more frequently than expected. Health care providers should be aware of the possibility of co-occurrence in their daily practice.
摘要：
春季角膜结膜炎（VKC）是一种双侧眼部炎性疾病，在儿童时期有结膜和角膜受累，典型发作。嗜酸性粒细胞性食管炎（EoE）是一种慢性疾病，其特征是粘膜嗜酸性粒细胞炎症（≥15嗜酸性粒细胞/HPF）和食管功能障碍的症状。EoE和VKC都是免疫介导的疾病，具有相似的致病机制，并且与其他过敏性疾病高度相关。然而，目前尚无有关其临床关联的数据.我们提供了4例同时诊断为春季角膜结膜炎和嗜酸性粒细胞食管炎的病例，表明这些疾病在同一患者中共存的频率可能比预期的要高。卫生保健提供者应该意识到在他们的日常实践中同时发生的可能性。
