PDF(Pubmed)
Abstract：
Psychedelic compounds have been utilized by humans for centuries for medicinal, religious, and tribal purposes. Clinical trial data starting from the early 2000s and continuing today indicates that psychedelics are a clinically efficacious treatment for a variety of neurological and psychiatric disorders. However, all clinical trials examining these substances have excluded any individual with a past or current history of seizures, leaving a large cohort of epilepsy and non-epilepsy chronic seizure disorder patients without anywhere to turn for psychedelic-assisted therapy. These exclusions were made despite any significant evidence that clinically supervised psychedelic use causes or exacerbates seizures in this population. To date, no clinical trial or preclinical seizure model has demonstrated that psychedelics induce seizures. This review highlights several cases of individuals experiencing seizures or seizure remission following psychedelic use, with the overall trend being that psychedelics are safe for use in a controlled, supervised clinical setting. We also suggest future research directions for this field.
摘要：
迷幻化合物已经被人类用于药用几个世纪，宗教,和部落的目的。从21世纪初开始并持续到今天的临床试验数据表明，迷幻药是各种神经和精神疾病的临床有效治疗方法。然而,所有检查这些物质的临床试验都排除了任何具有过去或当前癫痫发作史的个体，留下一大群癫痫和非癫痫慢性癫痫发作障碍患者，没有任何地方转向迷幻药辅助治疗。尽管有任何重要证据表明临床监督使用迷幻药会导致或加剧该人群的癫痫发作，但仍进行了这些排除。迄今为止,尚无临床试验或临床前癫痫发作模型证明迷幻药可诱发癫痫发作.这篇综述重点介绍了几例使用迷幻药后出现癫痫发作或癫痫发作缓解的个体，总体趋势是迷幻药在受控环境中使用是安全的，监督临床设置。我们还提出了该领域未来的研究方向。
