PDF(Pubmed)
Abstract：
UNASSIGNED: To identify independent risk factors for intraoperative in-stent thrombosis (IST) in paraclinoid aneurysms (PAs).
UNASSIGNED: 172 PA patents undergoing stent-assisted coiling (SAC) were divided into an IST group (n = 12) and a non-IST group (n = 160). Clinical characteristics, aneurysm morphologies, and laboratory parameters were measured. We performed independent t tests (for normally distributed data) or non-parametric tests (for non-normally distributed data) to compare continuous parameters. Multivariate logistic regression analysis with a stepwise forward method was conducted to determine independent risk factors. Receiver operating characteristic curves were generated, and the Delong test was employed for comparisons.
UNASSIGNED: Independent risk factors for IST included size ratio (SR) (p < 0.001, odds ratio [OR] = 3.909, confidence interval [CI] = 1.925-7.939), adenosine diphosphate (ADP) inhibition (p = 0.028, OR = 0.967, CI = 0.938-0.996), and reaction time (R) (p = 0.006, OR = 0.326, CI = 0.147-0.725). The combined factors (SR, ADP inhibition, and R) exhibited area under the curves of 0.870, 0.720, 0.716, and 0.697, with cutoff values of 2.46, 69.90%, and 4.65, respectively.
UNASSIGNED: The SR, ADP inhibition, and R values were independent risk factors for the IST in the PAs undergoing SAC. For PAs with a large SR, surgeons could prepare for long-term dual antiplatelet therapy before SAC.
UNASSIGNED: 172 PA patents undergoing stent-assisted coiling (SAC) were divided into an IST group (n = 12) and a non-IST group (n = 160). Clinical characteristics, aneurysm morphologies, and laboratory parameters were measured. We performed independent t tests (for normally distributed data) or non-parametric tests (for non-normally distributed data) to compare continuous parameters. Multivariate logistic regression analysis with a stepwise forward method was conducted to determine independent risk factors. Receiver operating characteristic curves were generated, and the Delong test was employed for comparisons.
UNASSIGNED: Independent risk factors for IST included size ratio (SR) (p < 0.001, odds ratio [OR] = 3.909, confidence interval [CI] = 1.925-7.939), adenosine diphosphate (ADP) inhibition (p = 0.028, OR = 0.967, CI = 0.938-0.996), and reaction time (R) (p = 0.006, OR = 0.326, CI = 0.147-0.725). The combined factors (SR, ADP inhibition, and R) exhibited area under the curves of 0.870, 0.720, 0.716, and 0.697, with cutoff values of 2.46, 69.90%, and 4.65, respectively.
UNASSIGNED: The SR, ADP inhibition, and R values were independent risk factors for the IST in the PAs undergoing SAC. For PAs with a large SR, surgeons could prepare for long-term dual antiplatelet therapy before SAC.
摘要：
■确定手术中支架内血栓形成（IST）的独立危险因素。
■172项接受支架辅助盘绕（SAC）的PA专利分为IST组（n=12）和非IST组（n=160）。临床特征,动脉瘤形态,和实验室参数进行了测量。我们进行了独立的t检验（对于正态分布数据）或非参数检验（对于非正态分布数据）来比较连续参数。采用逐步方法进行多因素logistic回归分析以确定独立的危险因素。生成接收器工作特性曲线，采用Delong检验进行比较。
■IST包含大小比（SR）的独立危险因素（p<0.001，比值比[OR]=3.909，置信区间[CI]=1.925-7.939），二磷酸腺苷（ADP）抑制（p=0.028，OR=0.967，CI=0.938-0.996），反应时间(R)(p=0.006,OR=0.326,CI=0.147-0.725)。综合因素(SR，ADP抑制,和R）表现出0.870、0.720、0.716和0.697的曲线下面积，截止值为2.46，69.90%，和4.65。
■SR，ADP抑制,和R值是接受SAC的PAs中IST的独立危险因素。对于具有大SR的PA，外科医生可以在SAC之前为长期双重抗血小板治疗做准备.
■172项接受支架辅助盘绕（SAC）的PA专利分为IST组（n=12）和非IST组（n=160）。临床特征,动脉瘤形态,和实验室参数进行了测量。我们进行了独立的t检验（对于正态分布数据）或非参数检验（对于非正态分布数据）来比较连续参数。采用逐步方法进行多因素logistic回归分析以确定独立的危险因素。生成接收器工作特性曲线，采用Delong检验进行比较。
■IST包含大小比（SR）的独立危险因素（p<0.001，比值比[OR]=3.909，置信区间[CI]=1.925-7.939），二磷酸腺苷（ADP）抑制（p=0.028，OR=0.967，CI=0.938-0.996），反应时间(R)(p=0.006,OR=0.326,CI=0.147-0.725)。综合因素(SR，ADP抑制,和R）表现出0.870、0.720、0.716和0.697的曲线下面积，截止值为2.46，69.90%，和4.65。
■SR，ADP抑制,和R值是接受SAC的PAs中IST的独立危险因素。对于具有大SR的PA，外科医生可以在SAC之前为长期双重抗血小板治疗做准备.
