PDF(Pubmed)
Abstract：
Introduction Human adenoviruses are common causes of many acute illnesses, and keratoconjunctivitis is one of them. Acute infections, if left untreated, can progress to severity, thus causing morbidities and mortalities. It belongs to the mastadenovirus family and is characterized by seven subgenus, i.e., A-G; among those, Adenovirus D8 is the most common type associated with keratoconjunctivitis. Methodology A hospital-based study was conducted, and the samples were collected from GB Pant Hospital, Port Blair, Dr Agarwals Eye Hospital, Port Blair, from August 2017 to December 2022. Clinical data and demographic details were followed by conjunctival swab sample collection from suspected keratoconjunctivitis patients. Samples were subjected to molecular screening, and Sanger sequencing was carried out for positive samples. Results Out of 506 conjunctival samples, a prevalence of 24.9% (n=126) was observed, and the commonest type circulating among the population of Andaman was Adenovirus D8. The major symptoms associated were eye redness (87.30%, n=110), followed by watering (81.75%, n=103), eye pain (72.22%, n=91), eye itching (61.11%, n=77), and discharge (50%, n=63). Conclusion In clinical research, ocular infections are one of the underrated fields. However, the study revealed the high prevalence of adenoviral infection among the suspected patients. Thus, there is a need for proper surveillance and timely diagnosis of such infections, as their severity may lead to loss of vision.
摘要：
人类腺病毒是许多急性疾病的常见原因，角膜结膜炎就是其中之一。急性感染,如果不及时治疗，可以进展到严重程度，从而导致发病率和死亡率。它属于乳腺腺病毒家族，具有七个亚属，即，A-G；其中，腺病毒D8是与角膜结膜炎相关的最常见类型。方法进行了一项以医院为基础的研究，样本是从GBPant医院收集的，布莱尔港,Agarwals医生眼科医院,布莱尔港,从2017年8月到2022年12月。从疑似角膜结膜炎患者的结膜拭子样本收集，然后收集临床数据和人口统计信息。样品经过分子筛选,对阳性样品进行Sanger测序。结果在506个结膜样本中，患病率为24.9%(n=126)，在安达曼人群中最常见的类型是腺病毒D8。主要症状为眼部红肿(87.30%,n=110),其次是浇水(81.75%，n=103),眼痛（72.22%，n=91),眼睛瘙痒（61.11%，n=77),和放电(50%，n=63）。结论在临床研究中,眼部感染是被低估的领域之一。然而,该研究显示，在疑似患者中，腺病毒感染的患病率很高。因此，需要对此类感染进行适当的监测和及时诊断，因为它们的严重程度可能导致视力丧失。
