PDF(Pubmed)
Abstract：
BACKGROUND: Epilepsy is caused by dysfunction in the brain, which is characterized by an enduring disposition for unprovoked seizures that reoccur often, along with the neurological, cognitive, psychological, and social effects of the condition, which are often managed with prolonged and sometimes lifelong medications that involve antiepileptic drugs (AEDs). To confirm the diagnosis of epilepsy, at least two unprovoked seizures occurring greater than 24 hours apart should be reported. This illness affects both children and adults. Patients with epilepsy are more likely to experience sexual dysfunction compared to the general population, which often leads to a poor quality of life. The pathophysiology involved consists of the impact of epilepsy and AEDs on the control of the hypothalamic-pituitary-gonadal axis, consequently resulting in a high risk of developing testicular or ovarian dysfunction, leading to sexual dysfunction in epilepsy patients.
OBJECTIVE: This review aims to highlight various studies focusing on the association of developing the risk of sexual dysfunction with psychiatric comorbidities, mainly depression and anxiety, that impact the quality of life in epilepsy patients.
METHODS: The search methodology involved articles from the Google Scholar and PubMed databases published between 2018 and 2023. \"Sexual dysfunction\", \"epilepsy\", \"depression\", \"anxiety\", and \"quality of life\" were the keywords used to search the articles. The Boolean operator \"AND\" and \"OR\" were used in between the keywords used. Following this, a total of 15 articles were included in the review based on the inclusion and exclusion criteria.
CONCLUSIONS: The review concluded that epilepsy patients are often affected by sexual dysfunction along with associated psychiatric comorbidities that mainly involve depression and anxiety, consequently impacting their quality of life, as demonstrated by various studies. Sexual dysfunction is a common yet underdiagnosed condition in epilepsy patients due to the stigma attached to it. Hence, neurologists must keep a high index of suspicion for this problem. Furthermore, screening and monitoring for sexual dysfunction should be added to the usual epilepsy work-up.
OBJECTIVE: This review aims to highlight various studies focusing on the association of developing the risk of sexual dysfunction with psychiatric comorbidities, mainly depression and anxiety, that impact the quality of life in epilepsy patients.
METHODS: The search methodology involved articles from the Google Scholar and PubMed databases published between 2018 and 2023. \"Sexual dysfunction\", \"epilepsy\", \"depression\", \"anxiety\", and \"quality of life\" were the keywords used to search the articles. The Boolean operator \"AND\" and \"OR\" were used in between the keywords used. Following this, a total of 15 articles were included in the review based on the inclusion and exclusion criteria.
CONCLUSIONS: The review concluded that epilepsy patients are often affected by sexual dysfunction along with associated psychiatric comorbidities that mainly involve depression and anxiety, consequently impacting their quality of life, as demonstrated by various studies. Sexual dysfunction is a common yet underdiagnosed condition in epilepsy patients due to the stigma attached to it. Hence, neurologists must keep a high index of suspicion for this problem. Furthermore, screening and monitoring for sexual dysfunction should be added to the usual epilepsy work-up.
摘要：
背景：癫痫是由大脑功能障碍引起的，其特点是对经常复发的无缘无故的癫痫发作有持久的处置，连同神经学，认知，心理,和条件的社会影响，通常使用涉及抗癫痫药（AEDs）的长期，有时是终生的药物进行管理。为了确认癫痫的诊断，应报告至少两次间隔超过24小时的无缘无故癫痫发作。这种疾病影响儿童和成人。与普通人群相比，癫痫患者更容易出现性功能障碍，这往往会导致生活质量低下。所涉及的病理生理学包括癫痫和AEDs对下丘脑-垂体-性腺轴控制的影响，因此导致睾丸或卵巢功能障碍的高风险，导致癫痫患者性功能障碍。
目的：本综述旨在强调关注发展性功能障碍与精神病合并症的风险的关联的各种研究。主要是抑郁和焦虑，影响癫痫患者的生活质量。
方法：搜索方法涉及2018年至2023年之间发布的GoogleScholar和PubMed数据库中的文章。“性功能障碍”，\"癫痫\",“抑郁症”，\"焦虑\",“生活质量”是用于搜索文章的关键词。使用的关键字之间使用了布尔运算符“AND”和“OR”。在此之后,根据纳入和排除标准,本综述共纳入15篇文章.
结论：该综述的结论是，癫痫患者通常会受到性功能障碍的影响，同时伴有主要涉及抑郁和焦虑的精神合并症，从而影响他们的生活质量，正如各种研究所证明的那样。性功能障碍是癫痫患者常见但未被诊断的疾病，因为它带有污名。因此，神经学家必须对这个问题保持高度怀疑。此外，在通常的癫痫检查中,应增加性功能障碍的筛查和监测.
目的：本综述旨在强调关注发展性功能障碍与精神病合并症的风险的关联的各种研究。主要是抑郁和焦虑，影响癫痫患者的生活质量。
方法：搜索方法涉及2018年至2023年之间发布的GoogleScholar和PubMed数据库中的文章。“性功能障碍”，\"癫痫\",“抑郁症”，\"焦虑\",“生活质量”是用于搜索文章的关键词。使用的关键字之间使用了布尔运算符“AND”和“OR”。在此之后,根据纳入和排除标准,本综述共纳入15篇文章.
结论：该综述的结论是，癫痫患者通常会受到性功能障碍的影响，同时伴有主要涉及抑郁和焦虑的精神合并症，从而影响他们的生活质量，正如各种研究所证明的那样。性功能障碍是癫痫患者常见但未被诊断的疾病，因为它带有污名。因此，神经学家必须对这个问题保持高度怀疑。此外，在通常的癫痫检查中,应增加性功能障碍的筛查和监测.
