PDF(Pubmed)
Abstract：
UNASSIGNED: This study aims to demonstrate the hemostatic effect of the hydroalcoholic extract of Achillea millefolium L. in localized bleeding and to assess the safety of its topical application on rat liver.
UNASSIGNED: The aerial parts of A. millefolium were macerated in methanol for two days. Twelve female Wistar rats, weighing 120-220 g, underwent anesthesia and laparotomy. The liver was exposed, and two incisions were made to induce bleeding. One incision was treated with a sponge soaked in A. millefolium extract, while the other served as a control. The animals were divided into two groups: in one, A. millefolium (150 mg/kg) was applied to the first incision, and in the other, to the second incision. Liver biopsies were collected after 4, 6, and 8 weeks.
UNASSIGNED: Application of A. millefolium to liver incisions, whether first or second, significantly reduced bleeding time (by 36.1% and 31.9%, respectively). Histopathological analysis showed no signs of toxicity or hepatic damage after 4, 6, and 8 weeks in the female rats.
UNASSIGNED: The study confirms the hemostatic effect of the hydroalcoholic extract of A. millefolium in localized bleeding and establishes its safety for topical use.
UNASSIGNED: The aerial parts of A. millefolium were macerated in methanol for two days. Twelve female Wistar rats, weighing 120-220 g, underwent anesthesia and laparotomy. The liver was exposed, and two incisions were made to induce bleeding. One incision was treated with a sponge soaked in A. millefolium extract, while the other served as a control. The animals were divided into two groups: in one, A. millefolium (150 mg/kg) was applied to the first incision, and in the other, to the second incision. Liver biopsies were collected after 4, 6, and 8 weeks.
UNASSIGNED: Application of A. millefolium to liver incisions, whether first or second, significantly reduced bleeding time (by 36.1% and 31.9%, respectively). Histopathological analysis showed no signs of toxicity or hepatic damage after 4, 6, and 8 weeks in the female rats.
UNASSIGNED: The study confirms the hemostatic effect of the hydroalcoholic extract of A. millefolium in localized bleeding and establishes its safety for topical use.
摘要：
■本研究旨在证明阿奇立叶水醇提取物在局部出血中的止血作用，并评估其局部应用于大鼠肝脏的安全性。
■将A.millefolium的地上部分在甲醇中浸渍两天。十二只雌性Wistar老鼠，重量120-220克，行麻醉和剖腹手术。肝脏暴露在外,做了两个切口来诱导出血。用浸泡在A.millefolium提取物中的海绵处理一个切口，而另一个作为一个控制。这些动物被分成两组：一组，将A.millefolium（150mg/kg）应用于第一个切口，在另一个，到第二个切口。在4、6和8周后收集肝活检。
■将A.millefolium应用于肝脏切口，无论是第一还是第二，显着减少出血时间（分别为36.1％和31.9％，分别)。组织病理学分析显示雌性大鼠在4、6和8周后没有毒性或肝损伤的迹象。
■该研究证实了A.millefolium水醇提取物在局部出血中的止血作用，并确立了其局部使用的安全性。
■将A.millefolium的地上部分在甲醇中浸渍两天。十二只雌性Wistar老鼠，重量120-220克，行麻醉和剖腹手术。肝脏暴露在外,做了两个切口来诱导出血。用浸泡在A.millefolium提取物中的海绵处理一个切口，而另一个作为一个控制。这些动物被分成两组：一组，将A.millefolium（150mg/kg）应用于第一个切口，在另一个，到第二个切口。在4、6和8周后收集肝活检。
■将A.millefolium应用于肝脏切口，无论是第一还是第二，显着减少出血时间（分别为36.1％和31.9％，分别)。组织病理学分析显示雌性大鼠在4、6和8周后没有毒性或肝损伤的迹象。
■该研究证实了A.millefolium水醇提取物在局部出血中的止血作用，并确立了其局部使用的安全性。
