UNASSIGNED: The aerial parts of A. millefolium were macerated in methanol for two days. Twelve female Wistar rats, weighing 120-220 g, underwent anesthesia and laparotomy. The liver was exposed, and two incisions were made to induce bleeding. One incision was treated with a sponge soaked in A. millefolium extract, while the other served as a control. The animals were divided into two groups: in one, A. millefolium (150 mg/kg) was applied to the first incision, and in the other, to the second incision. Liver biopsies were collected after 4, 6, and 8 weeks.
UNASSIGNED: Application of A. millefolium to liver incisions, whether first or second, significantly reduced bleeding time (by 36.1% and 31.9%, respectively). Histopathological analysis showed no signs of toxicity or hepatic damage after 4, 6, and 8 weeks in the female rats.
UNASSIGNED: The study confirms the hemostatic effect of the hydroalcoholic extract of A. millefolium in localized bleeding and establishes its safety for topical use.
■将A.millefolium的地上部分在甲醇中浸渍两天。十二只雌性Wistar老鼠,重量120-220克,行麻醉和剖腹手术。肝脏暴露在外,做了两个切口来诱导出血。用浸泡在A.millefolium提取物中的海绵处理一个切口,而另一个作为一个控制。这些动物被分成两组:一组,将A.millefolium(150mg/kg)应用于第一个切口,在另一个,到第二个切口。在4、6和8周后收集肝活检。
■将A.millefolium应用于肝脏切口,无论是第一还是第二,显着减少出血时间(分别为36.1%和31.9%,分别)。组织病理学分析显示雌性大鼠在4、6和8周后没有毒性或肝损伤的迹象。
■该研究证实了A.millefolium水醇提取物在局部出血中的止血作用,并确立了其局部使用的安全性。