PDF(Pubmed)
Abstract：
UNASSIGNED: Breast conserving surgery (BCS) followed by radiotherapy (BCT) and modified radical mastectomy (MRM) are the most common surgical techniques utilized in treatment of early breast cancer (EBC) with similar overall survival and recurrence rates. Western literature suggests that these treatments impact the quality of life (QOL) of patients variably. There are no comparison studies on these treatments as per patient\'s QOL in East Africa. The objectives were to compare the QOL of patients with EBC at least one year after BCT or MRM and assess the factors that affect this QOL.
UNASSIGNED: this was a cross-sectional study conducted at Aga Khan University Hospital-Nairobi (AKUHN). Eligible female patients with EBC who had undergone either BCT or MRM between January 2013 and December 2018 were invited to fill out European Organization for the Treatment and Research of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30). Data on participant demographics and clinical information was also obtained. Average scores for each aspect of QOL were obtained and overall means for each surgical treatment were compared. Linear regression was done to assess the factors that affected this QOL.
UNASSIGNED: forty-two patients had BCS/BCT and 39 had MRM. Patients who had undergone BCS/BCT had a better overall QOL than those who had undergone MRM (p=0.0149). Multivariate analysis revealed that five years from time of surgery, level of education and diabetes mellitus significantly (p<0.05) affected the QOL of these patients.
UNASSIGNED: after one year from surgery for EBC, patients who had undergone BCS/BCT had a better QOL as compared to MRM.
UNASSIGNED: this was a cross-sectional study conducted at Aga Khan University Hospital-Nairobi (AKUHN). Eligible female patients with EBC who had undergone either BCT or MRM between January 2013 and December 2018 were invited to fill out European Organization for the Treatment and Research of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30). Data on participant demographics and clinical information was also obtained. Average scores for each aspect of QOL were obtained and overall means for each surgical treatment were compared. Linear regression was done to assess the factors that affected this QOL.
UNASSIGNED: forty-two patients had BCS/BCT and 39 had MRM. Patients who had undergone BCS/BCT had a better overall QOL than those who had undergone MRM (p=0.0149). Multivariate analysis revealed that five years from time of surgery, level of education and diabetes mellitus significantly (p<0.05) affected the QOL of these patients.
UNASSIGNED: after one year from surgery for EBC, patients who had undergone BCS/BCT had a better QOL as compared to MRM.
摘要：
■保乳手术（BCS）后放疗（BCT）和改良根治术（MRM）是治疗早期乳腺癌（EBC）最常用的手术技术，总生存率和复发率相似。西方文献表明，这些治疗方法对患者的生活质量（QOL）有不同的影响。根据东非患者的生活质量，没有对这些治疗方法的比较研究。目的是比较BCT或MRM后至少一年的EBC患者的QOL，并评估影响该QOL的因素。
这是一项在阿加汗大学内罗毕医院（AKUHN）进行的横断面研究。邀请在2013年1月至2018年12月期间接受BCT或MRM的合格EBC女性患者填写欧洲癌症治疗和研究组织生活质量问卷（EORTC-QLQ-C30）。还获得了有关参与者人口统计学和临床信息的数据。获得QOL各个方面的平均得分，并比较每种手术治疗的总体平均值。进行线性回归以评估影响此QOL的因素。
■42例患者有BCS/BCT，39例患者有MRM。接受BCS/BCT的患者的总体生活质量优于接受MRM的患者（p=0.0149）。多因素分析显示，手术后五年，教育水平和糖尿病对这些患者的生活质量有显著影响(p<0.05)。
■在EBC手术一年后，与MRM相比,接受过BCS/BCT的患者的生活质量更好.
这是一项在阿加汗大学内罗毕医院（AKUHN）进行的横断面研究。邀请在2013年1月至2018年12月期间接受BCT或MRM的合格EBC女性患者填写欧洲癌症治疗和研究组织生活质量问卷（EORTC-QLQ-C30）。还获得了有关参与者人口统计学和临床信息的数据。获得QOL各个方面的平均得分，并比较每种手术治疗的总体平均值。进行线性回归以评估影响此QOL的因素。
■42例患者有BCS/BCT，39例患者有MRM。接受BCS/BCT的患者的总体生活质量优于接受MRM的患者（p=0.0149）。多因素分析显示，手术后五年，教育水平和糖尿病对这些患者的生活质量有显著影响(p<0.05)。
■在EBC手术一年后，与MRM相比,接受过BCS/BCT的患者的生活质量更好.
