PDF(Pubmed)
Abstract：
Anelloviruses (AVs) that infect the human population are members of the Anelloviridae family. They are widely distributed in human populations worldwide. Torque teno virus (TTV) was the first virus of this family to be identified and is estimated to be found in the serum of 80-90% of the human population. Sometime after the identification of TTV, Torque teno mini virus (TTMV) and Torque teno midi virus (TTMDV) were also identified and classified in this family. Since identifying these viruses, have been detected in various types of biological fluids of the human body, including blood and urine, as well as vital organs such as the liver and kidney. They can be transmitted from person to person through blood transfusions, fecal-oral contact, and possibly sexual intercourse. Recent studies on these newly introduced viruses show that although they are not directly related to human disease, they may be indirectly involved in initiating or exacerbating some human population-related diseases and viral infections. Among these diseases, we can mention various types of cancers, immune system diseases, viral infections, hepatitis, and AIDS. Also, they likely use the microRNAs (miRNAs) they encode to fulfill this cooperative role. Also, in recent years, the role of proliferation and their viral load, especially TTV, has been highlighted to indicate the immune system status of immunocompromised people or people who undergo organ transplants. Here, we review the possible role of these viruses in diseases that target humans and highlight them as important viruses that require further study. This review can provide new insights to researchers.
摘要：
感染人类群体的粘膜病毒(AV)是粘膜病毒科的成员。它们广泛分布于全球人群中。Torqueteno病毒（TTV）是该家族中第一个被鉴定的病毒，估计在80-90％的人群的血清中发现。在TTV被确认后的某个时候,在该家族中还鉴定并分类了扭矩特诺微型病毒（TTMV）和扭矩特诺微型病毒（TTMDV）。自从识别出这些病毒,已经在人体的各种类型的生物流体中检测到，包括血液和尿液,以及肝脏和肾脏等重要器官。它们可以通过输血在人与人之间传播，粪便-口腔接触，可能还有性交.最近对这些新引入的病毒的研究表明，尽管它们与人类疾病没有直接关系，它们可能间接参与引发或加剧一些人群相关疾病和病毒感染。在这些疾病中,我们可以提到各种类型的癌症，免疫系统疾病，病毒感染,肝炎，和艾滋病。此外，他们很可能使用他们编码的microRNAs（miRNAs）来完成这种合作角色。此外，近年来,增殖的作用及其病毒载量，尤其是TTV,已被强调以表明免疫功能低下的人或接受器官移植的人的免疫系统状态。这里,我们回顾了这些病毒在以人类为目标的疾病中的可能作用,并强调它们是需要进一步研究的重要病毒.这篇综述可以为研究人员提供新的见解。
