Abstract：
Objective: To investigate the role of the Abdominal Aortic Calcification-8 (AAC-8) scoring system in predicting restenosis or occlusion of lower extremity arteries after dilatation and angioplasty with drug-coated balloon (DCB). Methods: In this retrospective study, 62 patients who underwent dilatation and angioplasty with DCB for lower limb atherosclerotic obliterans (ASO) were enrolled from September 2018 to June 2022 in Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School. Among them who aged (73.9±11.3) years, 37 were males and 25 were females. Patients were divided into two groups according to the condition of the lower extremity arteries after dilatation and angioplasty with DCB: recurrence group (n=26) and patency group (n=36). Logistic regression was used to analyze the factors associated with restenosis or occlusion of lower extremity arteries after dilatation and angioplasty with DCB. The predictive value of the AAC-8 score for restenosis or occlusion of the lower extremity arteries after dilatation and angioplasty with DCB was analyzed using the receiver operating characteristic curves (ROC curves). Results: The postoperative follow-up was 16.30 (10.97, 24.10) months in the patency group and 9.03 (6.98, 15.31) months in the recurrence group. The results of multifactorial logistic regression analysis showed that an elevated AAC-8 score (OR=1.388, 95%CI: 1.067-1.806, P=0.015) was an associated factor of restenosis or occlusion of the lower extremity arteries after dilatation and angioplasty with DCB. The ROC curve analysis showed that the area under the curve (AUC) of the AAC-8 score for predicting restenosis or occlusion of the lower extremity arteries after dilatation and angioplasty with DCB was 0.687 (95%CI: 0.550-0.824, P=0.013), with a cut-off value of 5.5 points, a sensitivity of 65.4% and a specificity of 69.5%. Conclusions: Elevated AAC-8 score is associated with restenosis or occlusion of the lower extremity arteries after dilatation and angioplasty with DCB. When the cut-off value is 5.5, the AAC-8 score predicts restenosis or occlusion of the lower extremity arteries after DCB dilation and angioplasty with a sensitivity of 65.4% and a specificity of 69.5%.
目的： 探讨腹主动脉钙化-8（AAC-8）评分系统对药物涂层球囊（DCB）扩张成形术后下肢动脉再狭窄或闭塞的预测作用。 方法： 回顾性收集2018年9月至2022年6月南京大学医学院附属鼓楼医院因下肢动脉硬化闭塞症行DCB扩张成形术的62例患者的临床资料，其中男37例，女25例，年龄（73.9±11.3）岁。根据DCB扩张成形术后下肢动脉情况将患者分为两组：复发组（n=26）和通畅组（n=36）。采用logistic回归分析DCB扩张成形术后下肢动脉再狭窄或闭塞的相关因素。采用受试者工作特征（ROC）曲线分析AAC-8评分对DCB扩张成形术后下肢动脉再狭窄或闭塞的预测价值。 结果： 通畅组术后随访时间［M（Q1，Q3）］为16.30（10.97，24.10）个月，复发组术后随访时间为9.03（6.98，15.31）个月。多因素logistic回归分析结果显示，AAC-8评分升高（OR=1.388，95%CI：1.067~1.806，P=0.015）是DCB扩张成形术后下肢动脉再狭窄或闭塞的相关因素。ROC曲线分析结果显示，AAC-8评分预测DCB扩张成形术后下肢动脉再狭窄或闭塞的曲线下面积（AUC）为0.687（95%CI：0.550~0.824，P=0.013），cut-off值为5.5分，灵敏度为65.4%，特异度为69.5%。 结论： AAC-8评分升高是DCB扩张成形术后下肢动脉再狭窄或闭塞的相关因素。cut-off值为5.5分时，其预测DCB扩张成形术后下肢动脉再狭窄或闭塞的灵敏度为65.4%，特异度为69.5%。.
目的： 探讨腹主动脉钙化-8（AAC-8）评分系统对药物涂层球囊（DCB）扩张成形术后下肢动脉再狭窄或闭塞的预测作用。 方法： 回顾性收集2018年9月至2022年6月南京大学医学院附属鼓楼医院因下肢动脉硬化闭塞症行DCB扩张成形术的62例患者的临床资料，其中男37例，女25例，年龄（73.9±11.3）岁。根据DCB扩张成形术后下肢动脉情况将患者分为两组：复发组（n=26）和通畅组（n=36）。采用logistic回归分析DCB扩张成形术后下肢动脉再狭窄或闭塞的相关因素。采用受试者工作特征（ROC）曲线分析AAC-8评分对DCB扩张成形术后下肢动脉再狭窄或闭塞的预测价值。 结果： 通畅组术后随访时间［M（Q1，Q3）］为16.30（10.97，24.10）个月，复发组术后随访时间为9.03（6.98，15.31）个月。多因素logistic回归分析结果显示，AAC-8评分升高（OR=1.388，95%CI：1.067~1.806，P=0.015）是DCB扩张成形术后下肢动脉再狭窄或闭塞的相关因素。ROC曲线分析结果显示，AAC-8评分预测DCB扩张成形术后下肢动脉再狭窄或闭塞的曲线下面积（AUC）为0.687（95%CI：0.550~0.824，P=0.013），cut-off值为5.5分，灵敏度为65.4%，特异度为69.5%。 结论： AAC-8评分升高是DCB扩张成形术后下肢动脉再狭窄或闭塞的相关因素。cut-off值为5.5分时，其预测DCB扩张成形术后下肢动脉再狭窄或闭塞的灵敏度为65.4%，特异度为69.5%。.
摘要：
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