Abstract：
The phytochemical investigation of the pericarps of Caesalpinia bonduc led to the isolation and identification of five new cassane-type alkaloids: caesalminines C - G (1-5) and six new diterpenoids: caesalbonducin K - P (6-11), along with seven known compounds (12-18). Compounds 1-5 were identified as a group of rare alkaloids possessing a tetracyclic cassane-type diterpenoid skeleton with a lactam D-ring instead of a typical furan or lactone moiety. The structures of 1-11 were elucidated on the basis of 1D and 2D NMR including HSQC, HMBC, COSY and NOESY, and other spectroscopic analyses. The cytotoxic activities of the isolated compounds were evaluated in the A431, A549 and U87MG cancer cell lines.
摘要：
对Caesalpiniabonduc果皮的植物化学研究导致分离和鉴定了五种新的卡辛烷型生物碱：CaesalmininesC-G（1-5）和六种新的二萜：CaesalbonducinK-P（6-11），连同七个已知化合物(12-18)。化合物1-5被鉴定为一组稀有生物碱，具有四环的卡萨烷型二萜骨架，具有内酰胺D环代替典型的呋喃或内酯部分。1-11的结构在1D和2DNMR的基础上阐明，包括HSQC，HMBC,COSY和NOESY,和其他光谱分析。在A431，A549和U87MG癌细胞系中评估了分离化合物的细胞毒性活性。
