Abstract：
OBJECTIVE: Despite significant advancements in modern medicine, effective hepatoprotective medication with minimal side effects is still lacking. In this context. Tinospora cordifolia, an Indian Ayurvedic liana, has attracted much attention.
RESULTS: Traditionally, T. cordifolia has been found to be effective in the treatment of jaundice; according to the literature, T. cordifolia is a hepatoprotective agent, and the CCl4 model is the most frequently used to evaluate its potential. Its hepatoprotective effects might be attributed to alkaloids (berberine, palmatine, and jatrorrhizine) and sinapic acid. Berberine decreases inflammation by inhibiting the proinflammatory cascade triggered by TNF-α and reduces nitrosative stress by inhibiting iNOS. T. cordifolia also exhibits anticancer, anti-inflammatory, antimicrobial, antioxidant, and other activities; it is safe at concentrations up to 2000 mg/kg. Its biological action can be attributed to polyphenols, alkaloids, steroids, terpenoids, and glycosides. T. cordifolia has also been found to be an active ingredient in several polyherbal formulations used to treat chemical-mediated hepatotoxicity.
CONCLUSIONS: T. cordifolia\'s hepatoprotective effects are mediated by the inhibition of lipid peroxidation, the management of oxidative stress, and other factors. T. cordifolia can be used to manage liver disorders and as a hepatoprotective supplement in the food industry. The bioprospecting of its alkaloids can lead to the development of novel formulations against hepatic ailments.
RESULTS: Traditionally, T. cordifolia has been found to be effective in the treatment of jaundice; according to the literature, T. cordifolia is a hepatoprotective agent, and the CCl4 model is the most frequently used to evaluate its potential. Its hepatoprotective effects might be attributed to alkaloids (berberine, palmatine, and jatrorrhizine) and sinapic acid. Berberine decreases inflammation by inhibiting the proinflammatory cascade triggered by TNF-α and reduces nitrosative stress by inhibiting iNOS. T. cordifolia also exhibits anticancer, anti-inflammatory, antimicrobial, antioxidant, and other activities; it is safe at concentrations up to 2000 mg/kg. Its biological action can be attributed to polyphenols, alkaloids, steroids, terpenoids, and glycosides. T. cordifolia has also been found to be an active ingredient in several polyherbal formulations used to treat chemical-mediated hepatotoxicity.
CONCLUSIONS: T. cordifolia\'s hepatoprotective effects are mediated by the inhibition of lipid peroxidation, the management of oxidative stress, and other factors. T. cordifolia can be used to manage liver disorders and as a hepatoprotective supplement in the food industry. The bioprospecting of its alkaloids can lead to the development of novel formulations against hepatic ailments.
摘要：
目标：尽管现代医学取得了重大进展，仍然缺乏副作用最小的有效的保肝药物。在这种情况下。山孢,印度阿育吠陀藤本植物，引起了很多关注。
结果：传统上，T.cordifolia已被发现是有效的治疗黄疸;根据文献，T.Cordifolia是一种肝脏保护剂，CCl4模型是最常用来评估其潜力的模型。它的保肝作用可能归因于生物碱（小檗碱，巴马汀,和麻药）和芥子酸。小檗碱通过抑制TNF-α引发的促炎级联反应来减轻炎症，并通过抑制iNOS来减轻亚硝酸根应激。T.Cordifolia也表现出抗癌，抗炎,抗菌，抗氧化剂，和其他活动；浓度高达2000mg/kg时是安全的。其生物作用可归因于多酚，生物碱，类固醇,萜类化合物,和糖苷。还发现T.cordifolia是用于治疗化学介导的肝毒性的几种多草药制剂中的活性成分。
结论：T.科迪叶的保肝作用是通过抑制脂质过氧化作用介导的，氧化应激的管理，和其他因素。T.cordifolia可用于治疗肝脏疾病，并在食品工业中作为保肝补充剂。其生物碱的生物勘探可以导致针对肝脏疾病的新型制剂的开发。
结果：传统上，T.cordifolia已被发现是有效的治疗黄疸;根据文献，T.Cordifolia是一种肝脏保护剂，CCl4模型是最常用来评估其潜力的模型。它的保肝作用可能归因于生物碱（小檗碱，巴马汀,和麻药）和芥子酸。小檗碱通过抑制TNF-α引发的促炎级联反应来减轻炎症，并通过抑制iNOS来减轻亚硝酸根应激。T.Cordifolia也表现出抗癌，抗炎,抗菌，抗氧化剂，和其他活动；浓度高达2000mg/kg时是安全的。其生物作用可归因于多酚，生物碱，类固醇,萜类化合物,和糖苷。还发现T.cordifolia是用于治疗化学介导的肝毒性的几种多草药制剂中的活性成分。
结论：T.科迪叶的保肝作用是通过抑制脂质过氧化作用介导的，氧化应激的管理，和其他因素。T.cordifolia可用于治疗肝脏疾病，并在食品工业中作为保肝补充剂。其生物碱的生物勘探可以导致针对肝脏疾病的新型制剂的开发。
