PDF(Pubmed)
Abstract：
The enzymology of the key steps in the archaeal phospholipid biosynthetic pathway has been elucidated in recent years. In contrast, the complete biosynthetic pathways for proposed membrane regulators consisting of polyterpenes, such as carotenoids, respiratory quinones, and polyprenols remain unknown. Notably, the multiplicity of geranylgeranyl reductases (GGRs) in archaeal genomes has been correlated with the saturation of polyterpenes. Although GGRs, which are responsible for saturation of the isoprene chains of phospholipids, have been identified and studied in detail, there is little information regarding the structure and function of the paralogs. Here, we discuss the diversity of archaeal membrane-associated polyterpenes which is correlated with the genomic loci, structural and sequence-based analyses of GGR paralogs.
摘要：
近年来已经阐明了古细菌磷脂生物合成途径中关键步骤的酶学。相比之下,拟议的由多萜组成的膜调节剂的完整生物合成途径，如类胡萝卜素，呼吸醌,和聚戊烯醇仍然未知。值得注意的是,古细菌基因组中香叶基香叶基还原酶（GGR）的多重性与多萜的饱和度相关。虽然GGR,它们负责磷脂的异戊二烯链的饱和，已经被详细地识别和研究了，关于旁系物的结构和功能的信息很少。这里,我们讨论了与基因组基因座相关的古细菌膜相关多萜的多样性，GGR旁系同源物的基于结构和序列的分析。
