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Abstract：
Hepatocellular carcinoma (HCC) presents a significant global health challenge due to limited early detection methods, primarily relying on conventional approaches like imaging and alpha-fetoprotein (AFP). Although non-coding RNAs (ncRNAs) show promise as potential biomarkers in HCC, their true utility remains uncertain. We conducted a comprehensive review of 76 articles, analyzing 88 circulating lncRNAs in 6426 HCC patients. However, the lack of a standardized workflow protocol has hampered holistic comparisons across the literature. Consequently, we herein confined our meta-analysis to only a subset of these lncRNAs. The combined analysis of serum highly upregulated in liver cancer (HULC) gene expression with homeobox transcript antisense intergenic RNA (HOTAIR) and urothelial carcinoma-associated 1 (UCA1) demonstrated markedly enhanced sensitivity and specificity in diagnostic capability compared to traditional biomarkers or other ncRNAs. These findings could have substantial implications for the early diagnosis and tailored treatment of HCC.
摘要：
肝细胞癌（HCC）提出了一个重要的全球健康挑战，由于有限的早期检测方法，主要依靠常规方法，如成像和甲胎蛋白（AFP）。尽管非编码RNA（ncRNAs）有望作为HCC的潜在生物标志物，它们的真正效用仍然不确定。我们对76篇文章进行了全面审查，分析6426例HCC患者的88个循环lncRNAs。然而,缺乏标准化的工作流协议阻碍了文献中的整体比较.因此,在此，我们的荟萃分析仅限于这些lncRNAs的一个子集。与传统生物标志物或其他ncRNAs相比，血清高度上调的肝癌（HULC）基因表达与同源异型盒转录物反义基因间RNA（HOTAIR）和尿路上皮癌相关1（UCA1）的联合分析显示，诊断能力的敏感性和特异性显着增强。这些发现可能对HCC的早期诊断和定制治疗具有重要意义。
