Abstract：
The microbiota in the intermediate snail hosts of human schistosomes can significantly affect host biology. For decades, researchers have developed axenic snails to manipulate the symbiotic microbiota. This review summarizes the characteristics of symbiotic microbes in intermediate snail hosts and describes their interactions with snails, affecting snail growth, development, and parasite transmission ability. We focus on advances in axenic and gnotobiotic technologies for studying snail-microbe interactions and exploring the role of microbiota in snail susceptibility to Schistosoma infection. We discuss the challenges related to axenic and gnotobiotic snails, possible solutions to address these challenges, and future research directions to deepen our understanding of snail-microbiota interactions, with the aim to develop microbiota-based strategies for controlling snail populations and reducing their competence in transmitting parasites.
摘要：
人血吸虫中间蜗牛宿主中的微生物区系可以显着影响宿主生物学。几十年来,研究人员已经开发出无菌蜗牛来操纵共生微生物群。这篇综述总结了中间蜗牛宿主中共生微生物的特征，并描述了它们与蜗牛的相互作用，影响蜗牛的生长,发展,和寄生虫传播能力。我们专注于研究蜗牛-微生物相互作用和探索微生物群在蜗牛对血吸虫感染的易感性中的作用的轴突和微生物技术的进展。我们讨论了与轴突和侏儒蜗牛有关的挑战，应对这些挑战的可能解决方案，以及未来的研究方向，以加深我们对蜗牛-微生物群相互作用的理解，目的是开发基于微生物群的策略来控制蜗牛种群并降低其传播寄生虫的能力。
