PDF(Pubmed)
Abstract：
BACKGROUND: We provide updated crude and adjusted prevalence estimates of major birth defects in the United States for the period 2016-2020.
METHODS: Data were collected from 13 US population-based surveillance programs that used active or a combination of active and passive case ascertainment methods to collect all birth outcomes. These data were used to calculate pooled prevalence estimates and national prevalence estimates adjusted for maternal race/ethnicity for all conditions, and maternal age for trisomies and gastroschisis. Prevalence was compared to previously published national estimates from 1999 to 2014.
RESULTS: Adjusted national prevalence estimates per 10,000 live births ranged from 0.63 for common truncus to 18.65 for clubfoot. Temporal changes were observed for several birth defects, including increases in the prevalence of atrioventricular septal defect, tetralogy of Fallot, omphalocele, trisomy 18, and trisomy 21 (Down syndrome) and decreases in the prevalence of anencephaly, common truncus, transposition of the great arteries, and cleft lip with and without cleft palate.
CONCLUSIONS: This study provides updated national estimates of selected major birth defects in the United States. These data can be used for continued temporal monitoring of birth defects prevalence. Increases and decreases in prevalence since 1999 observed in this study warrant further investigation.
METHODS: Data were collected from 13 US population-based surveillance programs that used active or a combination of active and passive case ascertainment methods to collect all birth outcomes. These data were used to calculate pooled prevalence estimates and national prevalence estimates adjusted for maternal race/ethnicity for all conditions, and maternal age for trisomies and gastroschisis. Prevalence was compared to previously published national estimates from 1999 to 2014.
RESULTS: Adjusted national prevalence estimates per 10,000 live births ranged from 0.63 for common truncus to 18.65 for clubfoot. Temporal changes were observed for several birth defects, including increases in the prevalence of atrioventricular septal defect, tetralogy of Fallot, omphalocele, trisomy 18, and trisomy 21 (Down syndrome) and decreases in the prevalence of anencephaly, common truncus, transposition of the great arteries, and cleft lip with and without cleft palate.
CONCLUSIONS: This study provides updated national estimates of selected major birth defects in the United States. These data can be used for continued temporal monitoring of birth defects prevalence. Increases and decreases in prevalence since 1999 observed in this study warrant further investigation.
摘要：
背景：我们提供了美国2016-2020年期间主要出生缺陷的最新粗略和调整后的患病率估计。
方法：数据来自13个美国基于人群的监测项目，这些项目使用主动或主动和被动病例确定方法来收集所有出生结局。这些数据用于计算汇总的患病率估计值，并根据所有条件的孕产妇种族/种族调整了国家患病率估计值。三体和腹裂的产妇年龄。将患病率与1999年至2014年之前公布的国家估计进行了比较。
结果：调整后的全国患病率估计为每10,000例活产，范围从普通躯干的0.63到马蹄足的18.65。观察到几种出生缺陷的时间变化，包括房室间隔缺损患病率的增加，法洛四联症,脐膨出,18三体和21三体（唐氏综合征），无脑患病率降低，常见的干，大动脉转位,唇裂有和没有腭裂。
结论：本研究提供了对美国某些主要出生缺陷的最新国家估计。这些数据可用于出生缺陷患病率的持续时间监测。在这项研究中观察到的自1999年以来患病率的增加和减少值得进一步调查。
方法：数据来自13个美国基于人群的监测项目，这些项目使用主动或主动和被动病例确定方法来收集所有出生结局。这些数据用于计算汇总的患病率估计值，并根据所有条件的孕产妇种族/种族调整了国家患病率估计值。三体和腹裂的产妇年龄。将患病率与1999年至2014年之前公布的国家估计进行了比较。
结果：调整后的全国患病率估计为每10,000例活产，范围从普通躯干的0.63到马蹄足的18.65。观察到几种出生缺陷的时间变化，包括房室间隔缺损患病率的增加，法洛四联症,脐膨出,18三体和21三体（唐氏综合征），无脑患病率降低，常见的干，大动脉转位,唇裂有和没有腭裂。
结论：本研究提供了对美国某些主要出生缺陷的最新国家估计。这些数据可用于出生缺陷患病率的持续时间监测。在这项研究中观察到的自1999年以来患病率的增加和减少值得进一步调查。
